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פותח על ידי קלירמאש פתרונות בע"מ -
PHOTOCHEMICAL REACTIONS OF CHLORPROMAZINE; CHEMICAL AND BIOCHEMICAL IMPLICATIONS
Year:
1978
Source of publication :
Photochemistry and Photobiology
Authors :
רוזנטל, יונל
;
.
Volume :
28
Co-Authors:
Rosenthal, I., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Ben‐Hur, E., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Prager, A., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Riklis, E., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Facilitators :
From page:
591
To page:
594
(
Total pages:
4
)
Abstract:
Abstract— The photoexcited chlorpromazine reacts with methanol to yield promazine and 2‐methoxypromazine by two different reaction pathways: hydrogen atom abstraction and nucleophilic attack. respectively. When the photoexcitation of chlorpromazine is performed in the presence of protein or nucleic acids, chlorpromazine binds to the biopolymer. This binding is drastically pH‐dependent and correlates to the phototoxic effect exhibited in chlorpromazine—photosensitization of E. coli. No photodynamic damage of E. coli attributed to CPZ‐sensitization of molecular oxygen could be detected. Copyright © 1978, Wiley Blackwell. All rights reserved
Note:
Related Files :
animal experiment
chlorpromazine
DNA
Macromolecular Systems
Photosensitization
radioisotope
RNA
ultraviolet radiation
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1751-1097.1978.tb06975.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
23931
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:03
Scientific Publication
PHOTOCHEMICAL REACTIONS OF CHLORPROMAZINE; CHEMICAL AND BIOCHEMICAL IMPLICATIONS
28
Rosenthal, I., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Ben‐Hur, E., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Prager, A., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
Riklis, E., Israel Atomic Energy Commission, Nuclear Research Center-Negev, Beer-Sheva, Israel
PHOTOCHEMICAL REACTIONS OF CHLORPROMAZINE; CHEMICAL AND BIOCHEMICAL IMPLICATIONS
Abstract— The photoexcited chlorpromazine reacts with methanol to yield promazine and 2‐methoxypromazine by two different reaction pathways: hydrogen atom abstraction and nucleophilic attack. respectively. When the photoexcitation of chlorpromazine is performed in the presence of protein or nucleic acids, chlorpromazine binds to the biopolymer. This binding is drastically pH‐dependent and correlates to the phototoxic effect exhibited in chlorpromazine—photosensitization of E. coli. No photodynamic damage of E. coli attributed to CPZ‐sensitization of molecular oxygen could be detected. Copyright © 1978, Wiley Blackwell. All rights reserved
Scientific Publication
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