Co-Authors:
Shmiel, T., Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
Drori, R., Department of Physiology, Hebrew University, Jerusalem, Israel
Shmiel, O., Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
Ben-Shaul, Y., Department of Physiology, Hebrew University, Jerusalem, Israel
Nadasdy, Z., Division of Biology, California Institute of Technology, Pasadena, CA, United States
Shemesh, M., Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
Teicher, M., Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel
Abeles, M., Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel, Department of Physiology, Hebrew University, Jerusalem, Israel, Gonda Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel
Abstract:
Despite many reports indicating the existence of precise firing sequences in cortical activity, serious objections have been raised regarding the statistics used to detect them and the relations of these sequences to behavior. We show that in behaving monkeys, pairs of spikes from different neurons tend to prefer certain time delays when measured in relation to a specific behavior. Single-unit activity was recorded from eight microelectrodes inserted into the motor and premotor cortices of two monkeys while they were performing continuous drawinglike hand movements. Repeated scribbling paths, termed drawing components, were extracted by data-mining techniques. The set of the least predictable relations between drawing components and pairs of neurons was determined and represented by one statistic termed the relations score. The chance probability of the relations score was evaluated by teetering the spike times: 1,000 surrogates were generated by randomly teetering the original time of each spike in a small window. In nine of 13 experimental days the precision was better than 12 ms and, in the best case, spike precision reached 0.5 ms. Copyright © 2006 The American Physiological Society.
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