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פותח על ידי קלירמאש פתרונות בע"מ -
Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy
Year:
1995
Source of publication :
The American Journal of Medicine
Authors :
עזרא, דוד
;
.
Volume :
98
Co-Authors:
Shimon, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Almog, S., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Vered, Z., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Seligmann, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Shefi, M., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Peleg, E., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Rosenthal, T., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Motro, M., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Halkin, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Ezra, D., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Facilitators :
From page:
485
To page:
490
(
Total pages:
6
)
Abstract:
Purpose: We have previously found thiamine (vitamin B1) deficiency in patients with congestive heart failure (CHF) who had received long-term furosemide therapy. In the present study, we assessed the effect of thiamine repletion on thiamine status, functional capacity, and left ventricular ejection fraction (LVEF) in patients with moderate to severe CHF who had received furosemide in closes of 80 mg/d or more for at least 3 months. Patients and methods: Thirty patients were randomized to 1 week of double-blind inpatient therapy with either IV thiamine 200 mg/d or placebo (n = 15 each). All previous drugs were continued. Following discharge, all 30 patients received oral thiamine 200 mg/d as outpatients for 6 weeks. Thiamine status was determined by the erythrocyte thiamine-pyrophosphate effect (TPPE). LVEF was determined by echocardiography. Results: TPPE, diuresis, and LVEF were unchanged with IV placebo. After IV thiamine, TPPE decreased (11.7% ± 6.5% to 5.4% ± 3.2%; P <0.01). LVEF increased (0.28 ± 0.11 to 0.32 ± 0.09; P <0.05), as did diuresis (1,731 ± 800 mL/d to 2,389 ± 752 mL/d; P <0.02), and sodium excretion (84 ± 52 mEq/d to 116 ± 83 mEq/d, P <0.05). In the 27 patients completing the full 7-week intervention, LVEF rose by 22% (0.27 ± 0.10 to 0.33 ± 0.11, P <0.01). Conclusions: Thiamine repletion can improve left ventricular function and biochemical evidence of thiamine deficiency in some patients with moderate-to-severe CHF who are receiving long-term furosemide therapy. © 1995.
Note:
Related Files :
adult
clinical article
drug effect
Female
furosemide
intravenous drug administration
Male
vitamin deficiency
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0002-9343(99)80349-0
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
24091
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:05
Scientific Publication
Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy
98
Shimon, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Almog, S., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Vered, Z., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Seligmann, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Shefi, M., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Peleg, E., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Rosenthal, T., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Motro, M., Heart Institute, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Halkin, H., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Ezra, D., Division of Clinical Pharmacology, Department of Medicine A, Sheba Medical Center, Tel-Hashomer, Israel, Hypertension Unit, Sheba Medical Center, Tel-Hashomer, Israel
Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy
Purpose: We have previously found thiamine (vitamin B1) deficiency in patients with congestive heart failure (CHF) who had received long-term furosemide therapy. In the present study, we assessed the effect of thiamine repletion on thiamine status, functional capacity, and left ventricular ejection fraction (LVEF) in patients with moderate to severe CHF who had received furosemide in closes of 80 mg/d or more for at least 3 months. Patients and methods: Thirty patients were randomized to 1 week of double-blind inpatient therapy with either IV thiamine 200 mg/d or placebo (n = 15 each). All previous drugs were continued. Following discharge, all 30 patients received oral thiamine 200 mg/d as outpatients for 6 weeks. Thiamine status was determined by the erythrocyte thiamine-pyrophosphate effect (TPPE). LVEF was determined by echocardiography. Results: TPPE, diuresis, and LVEF were unchanged with IV placebo. After IV thiamine, TPPE decreased (11.7% ± 6.5% to 5.4% ± 3.2%; P <0.01). LVEF increased (0.28 ± 0.11 to 0.32 ± 0.09; P <0.05), as did diuresis (1,731 ± 800 mL/d to 2,389 ± 752 mL/d; P <0.02), and sodium excretion (84 ± 52 mEq/d to 116 ± 83 mEq/d, P <0.05). In the 27 patients completing the full 7-week intervention, LVEF rose by 22% (0.27 ± 0.10 to 0.33 ± 0.11, P <0.01). Conclusions: Thiamine repletion can improve left ventricular function and biochemical evidence of thiamine deficiency in some patients with moderate-to-severe CHF who are receiving long-term furosemide therapy. © 1995.
Scientific Publication
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