חיפוש מתקדם
British Journal of Haematology
Aloni, B., Research and Development Authority, Department of Biology, Ben-Gurion University of the Negev, Beer Sheva, Israel
Shinitzky, M., Laboratory of Membranes and Bioregulation, Weizmann Institute of Science, Rehovot, Israel
Moses, S., Department of Pediatrics, Soroka medical Center, Beer Sheva, Israel
Livne, A., Research and Development Authority, Department of Biology, Ben-Gurion University of the Negev, Beer Sheva, Israel
Erythrocytes affected by hereditary spherocytosis (HS), obtained from several splenectomized patients, showed a varying degree of elevated osmotic fragility. In order to evaluate a possible role of the crythrocyte membrane lipids in HS, microviscosity of the membrane lipid core was measured by a fluorescence‐polarization technique. Intact HS‐affected red cells, as well as their ghost membranes and liposomes prepared from their lipid extract, all showed a distinctly higher microviscosity than the respective normal control. The increased microviscosity correlated with the severity of HS. The data support the proposition that the defect in HS‐affected red cells is associated, at least in part, with alterations in the membrane lipids. Copyright © 1975, Wiley Blackwell. All rights reserved
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תנאי שימוש
Elevated Microviscosity in Membranes of Erythrocytes Affected by Hereditary Spherocytosis
31
Aloni, B., Research and Development Authority, Department of Biology, Ben-Gurion University of the Negev, Beer Sheva, Israel
Shinitzky, M., Laboratory of Membranes and Bioregulation, Weizmann Institute of Science, Rehovot, Israel
Moses, S., Department of Pediatrics, Soroka medical Center, Beer Sheva, Israel
Livne, A., Research and Development Authority, Department of Biology, Ben-Gurion University of the Negev, Beer Sheva, Israel
Elevated Microviscosity in Membranes of Erythrocytes Affected by Hereditary Spherocytosis
Erythrocytes affected by hereditary spherocytosis (HS), obtained from several splenectomized patients, showed a varying degree of elevated osmotic fragility. In order to evaluate a possible role of the crythrocyte membrane lipids in HS, microviscosity of the membrane lipid core was measured by a fluorescence‐polarization technique. Intact HS‐affected red cells, as well as their ghost membranes and liposomes prepared from their lipid extract, all showed a distinctly higher microviscosity than the respective normal control. The increased microviscosity correlated with the severity of HS. The data support the proposition that the defect in HS‐affected red cells is associated, at least in part, with alterations in the membrane lipids. Copyright © 1975, Wiley Blackwell. All rights reserved
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