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פותח על ידי קלירמאש פתרונות בע"מ -
GeneAnnot: Comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
Year:
2004
Source of publication :
bioinformatics (source)
Authors :
אופיר, רון
;
.
Volume :
20
Co-Authors:
Chalifa-Caspi, V., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Yanai, I., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Ophir, R., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Rosen, N., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Shmoish, M., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Benjamin-Rodrig, H., Dept. of Physics of Complex Systems, Weizmann Institute of Science, 76100 Rehovot, Israel
Shklar, M., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Stein, T.I., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Shmueli, O., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Safran, M., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Lancet, D., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Facilitators :
From page:
1457
To page:
1458
(
Total pages:
2
)
Abstract:
Motivation: High density oligonucleotide arrays are usually annotated in a one-to-one fashion, with each probeset assigned to one gene. However, in reality, subsets of oligonucleotides in a probeset may match sequences within more than one gene, potentially leading to misinterpretations. Moreover, a gene is often represented by more than one probeset, and analyzing probe matches at the mRNA level can help one deduce whether these probesets are derived from the same or different splice variants. Results: The GeneAnnot system comprehensively documents the many-to-many relationship between oligonucleotide array probesets and annotated genes in GeneCards™. It performs pairwise alignments between the probe sequences and gene transcripts, and assigns sensitivity and specificity scores to each probeset/gene pair. © Oxford University Press 2004; all rights reserved.
Note:
Related Files :
chromosome mapping
computer program
Documentation
gene mapping
oligonucleotide probe
sensitivity and specificity
sequence analysis
עוד תגיות
תוכן קשור
More details
DOI :
10.1093/bioinformatics/bth081
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
24410
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:07
Scientific Publication
GeneAnnot: Comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
20
Chalifa-Caspi, V., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Yanai, I., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Ophir, R., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Rosen, N., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Shmoish, M., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Benjamin-Rodrig, H., Dept. of Physics of Complex Systems, Weizmann Institute of Science, 76100 Rehovot, Israel
Shklar, M., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Stein, T.I., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Shmueli, O., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
Safran, M., Department of Biological Services, Weizmann Institute of Science, 76100 Rehovot, Israel
Lancet, D., Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
GeneAnnot: Comprehensive two-way linking between oligonucleotide array probesets and GeneCards genes
Motivation: High density oligonucleotide arrays are usually annotated in a one-to-one fashion, with each probeset assigned to one gene. However, in reality, subsets of oligonucleotides in a probeset may match sequences within more than one gene, potentially leading to misinterpretations. Moreover, a gene is often represented by more than one probeset, and analyzing probe matches at the mRNA level can help one deduce whether these probesets are derived from the same or different splice variants. Results: The GeneAnnot system comprehensively documents the many-to-many relationship between oligonucleotide array probesets and annotated genes in GeneCards™. It performs pairwise alignments between the probe sequences and gene transcripts, and assigns sensitivity and specificity scores to each probeset/gene pair. © Oxford University Press 2004; all rights reserved.
Scientific Publication
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