Fasting of 3-day-old chicks leads to changes in histone H3 methylation status

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Fasting of 3-day-old chicks leads to changes in histone H3 methylation status

Year: 

2012

Source of publication :

Physiology and Behavior

Authors :

מאירי, נעם

.

Volume :

105

Co-Authors: 

Xu, P., Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States
Denbow, C.J., Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States
Meiri, N., Institute of Animal Science, ARO, The Volcani Center, P.O. Box 6, Bet Dagan 50250, Israel
Denbow, D.M., Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States

From page: 

276

To page: 

282

(

Total pages: 

7

)

Link :

Fasting of 3-day-old chicks leads to changes in histone H3 methylation status

Abstract: 

Unfavorable nutritional conditions during early developmental periods may cause neuronal network remodeling in the hypothalamus, which influences subsequent adaptability to those same stressful conditions. Alterations in hypothalamic plasticity as a result of neuronal remodeling are achieved by variations in the repertoire of proteins expressed via gene transcriptional activation or repression, both of which are modulated by histone methylation status. This study demonstrates that fasting had a stimulatory effect on dimethylation and trimethylation of histone 3 at lysine 27 (H3K27) in preoptic/anterior hypothalamus (PO/AH) of 3-day-old chicks. The expression of enhancer of zeste 2 (EZH2), a H3K27-specific histone methyltransferase (HMT), was significantly increased by fasting in the paraventricular nucleus (PVN) and PO/AH, which is consistent with the upregulation of H3K27 dimethylation and trimethylation. Furthermore, in the PVN, corticotrophin-releasing hormone (CRH) mRNA expression was significantly inhibited, while mRNA expressions of thyrotropin-releasing hormone (TRH) and type 2 deiodinase (D2) were significantly stimulated by fasting. These findings highlight the potential role of H3K27 methylation status in early feed stress responses in chicks and may be indicative of an epigenetic mechanism for later adaptation to feed intake stress. © 2011 Elsevier Inc.