נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Biosynthesis of amphetamine analogs in plants
Year:
2012
Source of publication :
Trends in Plant Science
Authors :
לוינסון, אפרים
;
.
קריזבסקי, רז
;
.
Volume :
17
Co-Authors:
Hagel, J.M., Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Krizevski, R., Department of Aromatic Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, Po Box 1021, Ramat Yishay 30095, Israel
Marsolais, F., Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, London, ON N5 V 43T, Canada
Lewinsohn, E., Department of Aromatic Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, Po Box 1021, Ramat Yishay 30095, Israel
Facchini, P.J., Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Facilitators :
From page:
404
To page:
412
(
Total pages:
9
)
Abstract:
Amphetamine analogs are produced by plants in the genus Ephedra and by Catha edulis, and include the widely used decongestants and appetite suppressants pseudoephedrine and ephedrine. A combination of yeast (Candida utilis or Saccharomyces cerevisiae) fermentation and subsequent chemical modification is used for the commercial production of these compounds. The availability of certain plant biosynthetic genes would facilitate the engineering of yeast strains capable of de novo pseudoephedrine and ephedrine biosynthesis. Chemical synthesis has yielded amphetamine analogs with myriad functional group substitutions and diverse pharmacological properties. The isolation of enzymes with the serendipitous capacity to accept novel substrates could allow the production of substituted amphetamines in synthetic biosystems. Here, we review the biology, biochemistry and biotechnological potential of amphetamine analogs in plants. © 2012 Elsevier Ltd.
Note:
Related Files :
biosynthesis
Biosynthetic Pathways
Catha edulis
ephedrine
metabolism
Pichia jadinii
plant
Plants
Review
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.tplants.2012.03.004
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
סקירה
;
.
Language:
אנגלית
Editors' remarks:
ID:
24512
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:08
You may also be interested in
Scientific Publication
Biosynthesis of amphetamine analogs in plants
17
Hagel, J.M., Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Krizevski, R., Department of Aromatic Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, Po Box 1021, Ramat Yishay 30095, Israel
Marsolais, F., Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, London, ON N5 V 43T, Canada
Lewinsohn, E., Department of Aromatic Medicinal and Spice Crops, Newe Ya'ar Research Center, Agricultural Research Organization, Po Box 1021, Ramat Yishay 30095, Israel
Facchini, P.J., Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada
Biosynthesis of amphetamine analogs in plants
Amphetamine analogs are produced by plants in the genus Ephedra and by Catha edulis, and include the widely used decongestants and appetite suppressants pseudoephedrine and ephedrine. A combination of yeast (Candida utilis or Saccharomyces cerevisiae) fermentation and subsequent chemical modification is used for the commercial production of these compounds. The availability of certain plant biosynthetic genes would facilitate the engineering of yeast strains capable of de novo pseudoephedrine and ephedrine biosynthesis. Chemical synthesis has yielded amphetamine analogs with myriad functional group substitutions and diverse pharmacological properties. The isolation of enzymes with the serendipitous capacity to accept novel substrates could allow the production of substituted amphetamines in synthetic biosystems. Here, we review the biology, biochemistry and biotechnological potential of amphetamine analogs in plants. © 2012 Elsevier Ltd.
Scientific Publication
You may also be interested in