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פותח על ידי קלירמאש פתרונות בע"מ -
Human interleukin 2 receptor β-chain gene: Chromosomal localization and identification of 5' regulatory sequences
Year:
1990
Authors :
שרון, מיכל
;
.
Volume :
87
Co-Authors:
Gnarra, J.R., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Otani, H., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Wang, M.G., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
McBride, O.W., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Sharon, M., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Leonard, W.J., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Facilitators :
From page:
3440
To page:
3444
(
Total pages:
5
)
Abstract:
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2Rα chain and the 70-kDa IL-2Rβ chain. The low-affinity, IL-2Rα chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2Rβ receptor. We report here identification of the genomic locus for IL-2Rβ. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5'-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT)(n) class of middle repetitive elements, which may play an interesting regulatory role. The IL-2Rβ gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.
Note:
Related Files :
Base Sequence
chromosome mapping
Chromosomes, Human, Pair 22
Genes
genetic engineering
Oligonucleotide Probes
עוד תגיות
תוכן קשור
More details
DOI :
10.1073/pnas.87.9.3440
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
24792
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:10
You may also be interested in
Scientific Publication
Human interleukin 2 receptor β-chain gene: Chromosomal localization and identification of 5' regulatory sequences
87
Gnarra, J.R., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Otani, H., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Wang, M.G., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
McBride, O.W., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Sharon, M., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Leonard, W.J., Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, United States
Human interleukin 2 receptor β-chain gene: Chromosomal localization and identification of 5' regulatory sequences
Interleukin 2 (IL-2) binds to and stimulates activated T cells through high-affinity IL-2 receptors (IL-2Rs). Such receptors represent a complex consisting of at least two proteins, the 55-kDa IL-2Rα chain and the 70-kDa IL-2Rβ chain. The low-affinity, IL-2Rα chain cannot by itself transduce a mitogenic signal, whereas IL-2 stimulates resting lymphocytes through the intermediate-affinity, IL-2Rβ receptor. We report here identification of the genomic locus for IL-2Rβ. The exons are contained on four EcoRI fragments of 1.1, 9.2, 7.2, and 13.7 kilobases. The 1.1-kilobase EcoRI fragment lies at the 5'-most end of the genomic locus and contains promoter sequences. The promoter contains no TATA box-like elements but does contain the d(GT)(n) class of middle repetitive elements, which may play an interesting regulatory role. The IL-2Rβ gene is localized to chromosome 22q11.2-q12, a region that is the locus for several lymphoid neoplasias.
Scientific Publication
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