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פותח על ידי קלירמאש פתרונות בע"מ -
Long-lived αMUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity
Year:
2004
Authors :
יהב, שלמה
;
.
Volume :
1019
Co-Authors:
Tirosh, O., Inst. Biochem., Food Sci. and Nutr., Hebrew University of Jerusalem, Rehovot 76100, Israel
Schwartz, B., Inst. Biochem., Food Sci. and Nutr., Hebrew University of Jerusalem, Rehovot 76100, Israel
Zusman, I., Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel
Kossoy, G., Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel
Yahav, S., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Miskin, R., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Facilitators :
From page:
439
To page:
442
(
Total pages:
4
)
Abstract:
Caloric restriction (CR) is currently the only therapeutic intervention known to attenuate aging in mammals, but the mechanisms underlying this phenomenon are still poorly understood. To study this issue, the transgenic model of αMUPA mice, which previously were reported to spontaneously eat less and live longer compared with their wild-type (WT) control mice, were used. Currently, two transgenic lines that eat less are available, thus implicating the transgenic enzyme, that is, the urokinase-type plasminogen activator (uPA), in causing the reduced appetite. Recently, several changes in the αMUPA liver were noted, at the mitochondrial and cellular level, which consistently pointed to an enhanced capacity to induce apoptosis. In addition, αMUPA mice showed a reduced level of serum IGF-1 and a reduced incidence of spontaneously occurring or carcinogen-induced tumors in several tissues. Overall, the αMUPA model suggests that long-lasting, moderately increased apoptotic capacity, possibly linked in part to modulation of serum IGF-1 and mitochondrial functions, could play a role in the attenuation of aging in calorically restricted mice.
Note:
Related Files :
Animals
apoptosis
Appetite
Conference paper
Insulin-Like Growth Factor I
Mammalia
mice
עוד תגיות
תוכן קשור
More details
DOI :
10.1196/annals.1297.080
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
24879
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:10
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Scientific Publication
Long-lived αMUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity
1019
Tirosh, O., Inst. Biochem., Food Sci. and Nutr., Hebrew University of Jerusalem, Rehovot 76100, Israel
Schwartz, B., Inst. Biochem., Food Sci. and Nutr., Hebrew University of Jerusalem, Rehovot 76100, Israel
Zusman, I., Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel
Kossoy, G., Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel
Yahav, S., Institute of Animal Science, Agricultural Research Organization, Bet Dagan, Israel
Miskin, R., Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Long-lived αMUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity
Caloric restriction (CR) is currently the only therapeutic intervention known to attenuate aging in mammals, but the mechanisms underlying this phenomenon are still poorly understood. To study this issue, the transgenic model of αMUPA mice, which previously were reported to spontaneously eat less and live longer compared with their wild-type (WT) control mice, were used. Currently, two transgenic lines that eat less are available, thus implicating the transgenic enzyme, that is, the urokinase-type plasminogen activator (uPA), in causing the reduced appetite. Recently, several changes in the αMUPA liver were noted, at the mitochondrial and cellular level, which consistently pointed to an enhanced capacity to induce apoptosis. In addition, αMUPA mice showed a reduced level of serum IGF-1 and a reduced incidence of spontaneously occurring or carcinogen-induced tumors in several tissues. Overall, the αMUPA model suggests that long-lasting, moderately increased apoptotic capacity, possibly linked in part to modulation of serum IGF-1 and mitochondrial functions, could play a role in the attenuation of aging in calorically restricted mice.
Scientific Publication
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