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פותח על ידי קלירמאש פתרונות בע"מ -
14-3-3ε expression is induced during the critical period of thermal control establishment
Year:
2008
Source of publication :
Developmental Neurobiology
Authors :
מאירי, נעם
;
.
Volume :
68
Co-Authors:
Meiri, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
62
To page:
72
(
Total pages:
11
)
Abstract:
Signal-transduction mechanisms leading to neuronal plasticity involve a series of phosphorylation steps, which lead to transcription and de-novo protein synthesis. However, it is not clear how the specificity of the signal transduction achieved. Here, we evaluated the role of 14-3-3ε, a chaperone of phosphorylation and cellular-localization determination, in thermal control establishment, which represents hypothalamic plasticity, in chicks. As with other sensory mechanisms, there is a critical period in the development of temperature control. Neuroanatomically, body temperature is balanced by the preoptic anterior hypothalamus (PO/AH) and controlled by thermosensitive neurons. Hot or cold exposure during the critical period of temperature control development causes a plastic change in the ratio between hot- and cold-sensitive cells and can modulate temperature tolerance throughout life. It has been found that both mRNA and protein of isoform 14-3-3ε, but not other 14-3-3 isoforms, are induced during hot and cold conditioning in the PO/AH, with a peak at 24 h of conditioning. To determine whether 14-3-3ε has a general role in neuronal plasticity, we checked its expression after passive avoidance learning in the relevant neuroanatomical areas, i.e. the mesopallium intermediomediale and the striatum mediale. It was established that in these areas its expression was not altered after learning. The present study suggests that the correlative induction of both 14-3-3ε mRNA and protein many hours after learning is involved in plasticity in the hypothalamus but not in passive avoidance-related plasticity, which might indicate that specificity in the signal-transduction mechanism is at least partially mediated by 14-3-3. © 2007 Wiley Periodicals, Inc.
Note:
Related Files :
Animal
animal behavior
animal experiment
Animals
animal tissue
Chickens
metabolism
temperature
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/dneu.20571
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
24937
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:11
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14-3-3ε expression is induced during the critical period of thermal control establishment
68
Meiri, N., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
14-3-3ε expression is induced during the critical period of thermal control establishment
Signal-transduction mechanisms leading to neuronal plasticity involve a series of phosphorylation steps, which lead to transcription and de-novo protein synthesis. However, it is not clear how the specificity of the signal transduction achieved. Here, we evaluated the role of 14-3-3ε, a chaperone of phosphorylation and cellular-localization determination, in thermal control establishment, which represents hypothalamic plasticity, in chicks. As with other sensory mechanisms, there is a critical period in the development of temperature control. Neuroanatomically, body temperature is balanced by the preoptic anterior hypothalamus (PO/AH) and controlled by thermosensitive neurons. Hot or cold exposure during the critical period of temperature control development causes a plastic change in the ratio between hot- and cold-sensitive cells and can modulate temperature tolerance throughout life. It has been found that both mRNA and protein of isoform 14-3-3ε, but not other 14-3-3 isoforms, are induced during hot and cold conditioning in the PO/AH, with a peak at 24 h of conditioning. To determine whether 14-3-3ε has a general role in neuronal plasticity, we checked its expression after passive avoidance learning in the relevant neuroanatomical areas, i.e. the mesopallium intermediomediale and the striatum mediale. It was established that in these areas its expression was not altered after learning. The present study suggests that the correlative induction of both 14-3-3ε mRNA and protein many hours after learning is involved in plasticity in the hypothalamus but not in passive avoidance-related plasticity, which might indicate that specificity in the signal-transduction mechanism is at least partially mediated by 14-3-3. © 2007 Wiley Periodicals, Inc.
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