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פותח על ידי קלירמאש פתרונות בע"מ -
Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning
Year:
1994
Authors :
מאירי, נעם
;
.
Volume :
91
Co-Authors:
Meiri, N., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Masos, T., Department of Biochemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Rosenblum, K., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Miskin, R., Department of Biochemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Facilitators :
From page:
3196
To page:
3200
(
Total pages:
5
)
Abstract:
Transgenic mice designated αMUPA overproduce in the brain murine urokinase-type plasminogen activator (uPA), an extracellular protease implicated in tissue remodeling. We have now localized, by in situ hybridization, extensive signal of uPA mRNA in the αMUPA cortex, hippocampus, and amygdala, sites that were not labeled in counterpart wild- type mice. Furthermore, biochemical measurements reveal a remarkably high level of enzymatic activity of uPA in the cortex and hippocampus of αMUPA compared with wild-type mice. We have used the αMUPA mice to examine whether the abnormal level of uPA in the cortex and the limbic system affects learning ability. We report that αMUPA mice perform poorly in tasks of spatial, olfactory, and taste-aversion learning, while displaying normal sensory and motor capabilities. Our results suggest that uPA is involved in neural processes subserving a variety of learning types.
Note:
Related Files :
Animal
animal experiment
animal model
enzyme activity
gene expression
mice
Murinae
RNA, Messenger
עוד תגיות
תוכן קשור
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DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
24977
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:11
Scientific Publication
Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning
91
Meiri, N., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Masos, T., Department of Biochemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Rosenblum, K., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Miskin, R., Department of Biochemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Dudai, Y., Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning
Transgenic mice designated αMUPA overproduce in the brain murine urokinase-type plasminogen activator (uPA), an extracellular protease implicated in tissue remodeling. We have now localized, by in situ hybridization, extensive signal of uPA mRNA in the αMUPA cortex, hippocampus, and amygdala, sites that were not labeled in counterpart wild- type mice. Furthermore, biochemical measurements reveal a remarkably high level of enzymatic activity of uPA in the cortex and hippocampus of αMUPA compared with wild-type mice. We have used the αMUPA mice to examine whether the abnormal level of uPA in the cortex and the limbic system affects learning ability. We report that αMUPA mice perform poorly in tasks of spatial, olfactory, and taste-aversion learning, while displaying normal sensory and motor capabilities. Our results suggest that uPA is involved in neural processes subserving a variety of learning types.
Scientific Publication
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