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פותח על ידי קלירמאש פתרונות בע"מ -
β-Caryophyllene, a compound isolated from the biblical balm of gilead (Commiphora gileadensis), is a selective apoptosis inducer for tumor cell lines
Year:
2012
Authors :
דודאי, נתיב
;
.
Volume :
2012
Co-Authors:
Amiel, E., French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
Ofir, R., Dead Sea and Arava Science Center, Dead Sea 86910, Israel, Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot 88840, Israel
Dudai, N., Unit of Medicinal and Aromatic Plants, Newe ya'Ar Research Center, Ramat Ishai 30095, Israel
Soloway, E., Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Rabinsky, T., Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot 88840, Israel
Rachmilevitch, S., French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
Facilitators :
From page:
To page:
(
Total pages:
1
)
Abstract:
The biblical balm of Gilead (Commiphora gileadensis) was investigated in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that -caryophyllene (trans-(1R,9S)-8-methylene-4,11,11-trimethylbicyclo[7.2.0]undec- 4-ene) is a key component in essential oils extracted from the balm of Gilead. -Caryophyllene can be found in spice blends, citrus flavors, soaps, detergents, creams, and lotions, as well as in a variety of food and beverage products, and it is known for its anti-inflammatory, local anaesthetic, and antifungal properties. It is also a potent cytotoxic compound over a wide range of cell lines. In the current paper, we found that Commiphora gileadensis stem extracts and essential oil have an antiproliferative proapoptotic effect against tumor cells and not against normal cells. -caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis stems contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells. Copyright © 2012 Eitan Amiel et al.
Note:
Related Files :
alcohol
animal cell
apoptosis
Commiphora
enzyme activity
human cell
Judean balsam
mouse
plant stem
עוד תגיות
תוכן קשור
More details
DOI :
10.1155/2012/872394
Article number:
872394
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
25325
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:14
You may also be interested in
Scientific Publication
β-Caryophyllene, a compound isolated from the biblical balm of gilead (Commiphora gileadensis), is a selective apoptosis inducer for tumor cell lines
2012
Amiel, E., French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
Ofir, R., Dead Sea and Arava Science Center, Dead Sea 86910, Israel, Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot 88840, Israel
Dudai, N., Unit of Medicinal and Aromatic Plants, Newe ya'Ar Research Center, Ramat Ishai 30095, Israel
Soloway, E., Department of Microbiology and Immunology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
Rabinsky, T., Center for Sustainable Agriculture, Arava Institute for Environmental Studies, D.N. Hevel Eilot 88840, Israel
Rachmilevitch, S., French Associates Institute for Agriculture and Biotechnology of Drylands, Ben Gurion University of the Negev, Sede-Boqer Campus, Midreshet Ben Gurion 84990, Israel
β-Caryophyllene, a compound isolated from the biblical balm of gilead (Commiphora gileadensis), is a selective apoptosis inducer for tumor cell lines
The biblical balm of Gilead (Commiphora gileadensis) was investigated in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that -caryophyllene (trans-(1R,9S)-8-methylene-4,11,11-trimethylbicyclo[7.2.0]undec- 4-ene) is a key component in essential oils extracted from the balm of Gilead. -Caryophyllene can be found in spice blends, citrus flavors, soaps, detergents, creams, and lotions, as well as in a variety of food and beverage products, and it is known for its anti-inflammatory, local anaesthetic, and antifungal properties. It is also a potent cytotoxic compound over a wide range of cell lines. In the current paper, we found that Commiphora gileadensis stem extracts and essential oil have an antiproliferative proapoptotic effect against tumor cells and not against normal cells. -caryophyllene caused a potent induction of apoptosis accompanied by DNA ladder and caspase-3 catalytic activity in tumor cell lines. In summary, we showed that C. gileadensis stems contain an apoptosis inducer that acts, in a selective manner, against tumor cell lines and not against normal cells. Copyright © 2012 Eitan Amiel et al.
Scientific Publication
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