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קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia
Year:
1999
Authors :
בן-בסט, שגיא
;
.
גנין, אולגה
;
.
לבלין, אירינה
;
.
פינס, מרק
;
.
Volume :
149
Co-Authors:
Ben-Bassat, S., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Genina, O., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Lavelin, I., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Leach, R.M., Department of Poultry Sciences, Pennsylvania State University, University Park, PA 16802-3501, United States
Pines, M., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Facilitators :
From page:
185
To page:
195
(
Total pages:
11
)
Abstract:
PTH/PTHrP receptor gene expression was evaluated in situ in avian epiphyseal growth plates taken from normal, rachitic and tibial dyschondroplasia (TD) afflicted chicks induced by thiram or by genetic selection. In the normal growth plates, PTH/PTHrP receptor gene expression was localized to the maturation zone as demonstrated by the expression of collagen type II (col II), osteopontin (OPN) genes and alkaline phosphatase activity (AP). In TD, either induced by thiram or by genetic selection, normal levels of PTH/PTHrP receptor gene expression were observed up to 21 days post-hatch. In rickets, on the other hand, no PTH/PTHrP receptor gene expression was observed in the growth plate from day 8 of a vitamin D- deficient diet. In cultured chondrocytes, PTH caused time-dependent down- regulation of its own receptor. These results suggest that alterations in the PTH/PTHrP receptor gene expression are associated with rickets but not with TD. The reduction in the PTH/PTHrP receptor gene expression in rickets may be due to the high plasma levels of PTH.
Note:
Related Files :
animal experiment
animal model
Animals
animal tissue
gene expression
Growth plate
Male
Osteochondrodysplasias
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/S0303-7207(98)00231-7
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
25476
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:15
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Scientific Publication
Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia
149
Ben-Bassat, S., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Genina, O., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Lavelin, I., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Leach, R.M., Department of Poultry Sciences, Pennsylvania State University, University Park, PA 16802-3501, United States
Pines, M., Institute of Animal Science, Agric. Res. Org., Volcani Ctr., P.O., Bet Dagan, Israel
Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia
PTH/PTHrP receptor gene expression was evaluated in situ in avian epiphyseal growth plates taken from normal, rachitic and tibial dyschondroplasia (TD) afflicted chicks induced by thiram or by genetic selection. In the normal growth plates, PTH/PTHrP receptor gene expression was localized to the maturation zone as demonstrated by the expression of collagen type II (col II), osteopontin (OPN) genes and alkaline phosphatase activity (AP). In TD, either induced by thiram or by genetic selection, normal levels of PTH/PTHrP receptor gene expression were observed up to 21 days post-hatch. In rickets, on the other hand, no PTH/PTHrP receptor gene expression was observed in the growth plate from day 8 of a vitamin D- deficient diet. In cultured chondrocytes, PTH caused time-dependent down- regulation of its own receptor. These results suggest that alterations in the PTH/PTHrP receptor gene expression are associated with rickets but not with TD. The reduction in the PTH/PTHrP receptor gene expression in rickets may be due to the high plasma levels of PTH.
Scientific Publication
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