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אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Treatment of murine systemic aspergillosis with polyene-intralipid admixtures
Year:
2004
Source of publication :
Medical Mycology
Authors :
סיונוב, אדוארד
;
.
Volume :
42
Co-Authors:
Sionov, E., Department of Human Microbiology, Tel-Aviv University, Sackler School of Medicine, Tel-Aviv 69978, Israel
Segal, E., Department of Human Microbiology, Tel-Aviv University, Sackler School of Medicine, Tel-Aviv 69978, Israel
Facilitators :
From page:
73
To page:
80
(
Total pages:
8
)
Abstract:
The objective of this research was the evaluation of the activity of admixtures of amphotericin B (AMB) - intralipid (AMB-IL) and nystatin (Ny) - intralipid (Ny-IL) against experimental systemic aspergillosis in immunocompromised mice. ICR mice were transiently immunosuppressed by intraperitoneal (i.p.) administration of cyclophosphamide (CY). Three days post CY administration the mice were inoculated intravenously (i.v.) with Aspergillus fumigatus conidia. The animals were treated with various doses of AMB-IL or Ny-IL admixtures administered i.v. for 5 consecutive days, starting 2 h after infection. The mean survival rate (MSR) and mean survival time (MST) were evaluated during an observation period of 30 days in comparison to untreated infected mice and to animals treated with conventional formulations of these drugs. These experiments showed that AMB-IL increased significantly the MSR. Specifically, the MSR ranged in dependence of dose, between 48 and 65.7% vs. 0% of the untreated (P < 0.001, anova analysis) and 39.7% of AMB-treated animals (P < 0.01). The MSR of the Ny-IL-treated mice ranged between 16.2 and 40% in comparison to 0% of the untreated group (P < 0.001). Treatment with both admixtures prolonged the MST of the mice (AMB-IL: 17.3-23.07 days; Ny-IL: 8.61-16.8 days) in comparison to either untreated (6.13 days) or AMB treated animals (15.23 days). The data obtained in this study show that both AMB-IL and Ny-IL formulations, particularly AMB-IL at the highest dose, were effective in the treatment of experimental systemic aspergillosis.
Note:
Related Files :
animal experiment
Animals
Antibiotics, Antifungal
Aspergillus
Female
mice
עוד תגיות
תוכן קשור
More details
DOI :
10.1080/13693780310001598871
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
25586
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:16
Scientific Publication
Treatment of murine systemic aspergillosis with polyene-intralipid admixtures
42
Sionov, E., Department of Human Microbiology, Tel-Aviv University, Sackler School of Medicine, Tel-Aviv 69978, Israel
Segal, E., Department of Human Microbiology, Tel-Aviv University, Sackler School of Medicine, Tel-Aviv 69978, Israel
Treatment of murine systemic aspergillosis with polyene-intralipid admixtures
The objective of this research was the evaluation of the activity of admixtures of amphotericin B (AMB) - intralipid (AMB-IL) and nystatin (Ny) - intralipid (Ny-IL) against experimental systemic aspergillosis in immunocompromised mice. ICR mice were transiently immunosuppressed by intraperitoneal (i.p.) administration of cyclophosphamide (CY). Three days post CY administration the mice were inoculated intravenously (i.v.) with Aspergillus fumigatus conidia. The animals were treated with various doses of AMB-IL or Ny-IL admixtures administered i.v. for 5 consecutive days, starting 2 h after infection. The mean survival rate (MSR) and mean survival time (MST) were evaluated during an observation period of 30 days in comparison to untreated infected mice and to animals treated with conventional formulations of these drugs. These experiments showed that AMB-IL increased significantly the MSR. Specifically, the MSR ranged in dependence of dose, between 48 and 65.7% vs. 0% of the untreated (P < 0.001, anova analysis) and 39.7% of AMB-treated animals (P < 0.01). The MSR of the Ny-IL-treated mice ranged between 16.2 and 40% in comparison to 0% of the untreated group (P < 0.001). Treatment with both admixtures prolonged the MST of the mice (AMB-IL: 17.3-23.07 days; Ny-IL: 8.61-16.8 days) in comparison to either untreated (6.13 days) or AMB treated animals (15.23 days). The data obtained in this study show that both AMB-IL and Ny-IL formulations, particularly AMB-IL at the highest dose, were effective in the treatment of experimental systemic aspergillosis.
Scientific Publication
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