peptides (מקור פרסום )
Altstein, M., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Ben-Aziz, O., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Zeltser, I., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Bhargava, K., Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri, Kansas City, MO 64110, United States
Davidovitch, M., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Strey, A., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
Pryor, N., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
Nachman, R.J., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
The antagonistic properties of a few linear and backbone cyclic (BBC) conformationally constraint peptide libraries and their analogs, were tested for the ability to inhibit pyrokinin/pheromone biosynthesis activating neuropeptide (PK/PBAN) mediated functions: sex pheromone biosynthesis in Heliothis peltigera female moths, cuticular melanization in Spodoptera littoralis larvae, pupariation in the fleshfly Neobellieria bullata and hindgut contraction in Leucophaea maderae, elicited by exogenously injected PBAN, pheromonotropin (PT), leucopyrokinin (LPK), myotropin (MT) or by the endogenous peptides. The data revealed differential inhibitory patterns within the same assay with different elicitors (in both the pheromonotropic and melanotropic assays) and among the different functions and disclosed selective antagonists, hinting at the possibility that the receptors that mediate those functions may differ from one another structurally. © 2007 Elsevier Inc. All rights reserved.
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Inhibition of PK/PBAN-mediated functions in insects: Discovery of selective and non-selective inhibitors
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Altstein, M., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Ben-Aziz, O., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Zeltser, I., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Bhargava, K., Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri, Kansas City, MO 64110, United States
Davidovitch, M., Department of Entomology, The Volcani Center, Bet Dagan, 50250, Israel
Strey, A., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
Pryor, N., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
Nachman, R.J., Areawide Pest Management Research, Southern Plains Agricultural Research Center, U.S. Department of Agriculture, College Station, TX 77845, United States
Inhibition of PK/PBAN-mediated functions in insects: Discovery of selective and non-selective inhibitors
The antagonistic properties of a few linear and backbone cyclic (BBC) conformationally constraint peptide libraries and their analogs, were tested for the ability to inhibit pyrokinin/pheromone biosynthesis activating neuropeptide (PK/PBAN) mediated functions: sex pheromone biosynthesis in Heliothis peltigera female moths, cuticular melanization in Spodoptera littoralis larvae, pupariation in the fleshfly Neobellieria bullata and hindgut contraction in Leucophaea maderae, elicited by exogenously injected PBAN, pheromonotropin (PT), leucopyrokinin (LPK), myotropin (MT) or by the endogenous peptides. The data revealed differential inhibitory patterns within the same assay with different elicitors (in both the pheromonotropic and melanotropic assays) and among the different functions and disclosed selective antagonists, hinting at the possibility that the receptors that mediate those functions may differ from one another structurally. © 2007 Elsevier Inc. All rights reserved.
Scientific Publication