נגישות
menu      
חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
The effect of the plasma levels of proteins C and S on the prediction of warfarin maintenance dose requirements
Year:
1992
Authors :
עזרא, דוד
;
.
Volume :
52
Co-Authors:
Lubetsky, A., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Seligsohn, U., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Halkin, H., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Facilitators :
From page:
42
To page:
49
(
Total pages:
8
)
Abstract:
Objective: Determination of the effects of the vitamin K—dependent anticoagulants, proteins C and S, on warfarin dose requirements and on the prediction error of a bayesian warfarin dose predicting program. Methods: Patients in the study were consecutive inpatients (n = 18) starting treatment with warfarin who were monitored as outpatients for 4 weeks. The following measurements were taken: repeated (n = 8) prothrombin times, expressed as the international normalized ratio (INR), plasma protein C and S antigen levels (percentage of pooled normal plasma), demographic, clinical and biochemical variables. Results: Maintenance doses (adjusted to INR 2.5) were 6.7 ± 3.4 mg/day. Protein C decreased to 56.9% ± 15.3%, protein S to 63.7% ± 17.3%, INR increased to 2.46 ± 0.14. Prediction error decreased from 2.84 ± 2.0 mg/day to 0.95 ± 0.78 mg/day. Protein C accounted for only 4.2% of the mean maintenance dose but protein C and S levels accounted for 31% of the mean dose prediction error. Conclusion: Protein C and S levels affect warfarin doses and predictions significantly but not to a clinically meaningful degree. Clinical Pharmacology and Therapeutics (1992) 52, 42–49; doi: © 1992 American Society for Clinical Pharmacology and Therapeutics
Note:
Related Files :
adult
aged
clinical article
drug blood level
Female
human
Male
oral drug administration
prothrombin time
regression analysis
עוד תגיות
תוכן קשור
More details
DOI :
10.1038/clpt.1992.101
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
25877
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:18
You may also be interested in
Scientific Publication
The effect of the plasma levels of proteins C and S on the prediction of warfarin maintenance dose requirements
52
Lubetsky, A., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Seligsohn, U., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Ezra, D., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Halkin, H., Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel, Institute of Hematology, Ichilov Hospital, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
The effect of the plasma levels of proteins C and S on the prediction of warfarin maintenance dose requirements
Objective: Determination of the effects of the vitamin K—dependent anticoagulants, proteins C and S, on warfarin dose requirements and on the prediction error of a bayesian warfarin dose predicting program. Methods: Patients in the study were consecutive inpatients (n = 18) starting treatment with warfarin who were monitored as outpatients for 4 weeks. The following measurements were taken: repeated (n = 8) prothrombin times, expressed as the international normalized ratio (INR), plasma protein C and S antigen levels (percentage of pooled normal plasma), demographic, clinical and biochemical variables. Results: Maintenance doses (adjusted to INR 2.5) were 6.7 ± 3.4 mg/day. Protein C decreased to 56.9% ± 15.3%, protein S to 63.7% ± 17.3%, INR increased to 2.46 ± 0.14. Prediction error decreased from 2.84 ± 2.0 mg/day to 0.95 ± 0.78 mg/day. Protein C accounted for only 4.2% of the mean maintenance dose but protein C and S levels accounted for 31% of the mean dose prediction error. Conclusion: Protein C and S levels affect warfarin doses and predictions significantly but not to a clinically meaningful degree. Clinical Pharmacology and Therapeutics (1992) 52, 42–49; doi: © 1992 American Society for Clinical Pharmacology and Therapeutics
Scientific Publication
You may also be interested in