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פותח על ידי קלירמאש פתרונות בע"מ -
Embryonic cultures but not embryos transplanted to the mouse's brain grow rapidly without immunosuppression
Year:
1995
Authors :
שני, משה
;
.
Volume :
81
Co-Authors:
Yanai, J., The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Box 1172, 91010, Jerusalem, Israel
Doetchman, T., Dept. of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH, 45267, United States
Laufer, N., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Maslaton, J., The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Box 1172, 91010, Jerusalem, Israel
Mor-Yosef, S., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Safran, A., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Shani, M., Institute for Animal Science, The Volcani Center, Bet Dagan, 50250, Israel
Sofer, D., Dept. of Pathology (Neuropathology), Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Facilitators :
From page:
21
To page:
26
(
Total pages:
6
)
Abstract:
Embryos and embryocultures can be successfully transplanted into various bodily organs. However, immunosuppression or homogenicity are required for the success of such experimental manipulation. Since the brain is considered immunologically privileged, we transplanted 2-4 cell embryos of C57BL x BALB/c, embryonic stem cells (ES) or embryoid bodies (EB) cultures into the hippocampus of the heterogeneous mouse stock HSMBg. Both ES and EB cultures developed into an extensive growth, eventually larger than the brain itself, causing the death of the host in less than 29 days. The growth was identified as teratoma, mostly made of immature cells and tissues of diverse origin. Thus, the overall histological picture was that of a malignant teratoma. On the other hand, no embryos were found at any time after the transplantation; apparently, they could not survive in the host brain. The growth rate and the relative lack of rejection suggest that the brain offers a unique medium for ES and EB cultures but, not to embryos. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Note:
Related Files :
Animal
brain transplantation
fetal tissue transplantation
mice
Pathology
tissue culture
Transplantation
ultrastructure
עוד תגיות
תוכן קשור
More details
DOI :
10.3109/00207459509015295
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26059
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:19
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Scientific Publication
Embryonic cultures but not embryos transplanted to the mouse's brain grow rapidly without immunosuppression
81
Yanai, J., The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Box 1172, 91010, Jerusalem, Israel
Doetchman, T., Dept. of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, OH, 45267, United States
Laufer, N., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Maslaton, J., The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Box 1172, 91010, Jerusalem, Israel
Mor-Yosef, S., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Safran, A., IVF Unit, Dept. Obstetrics and Gynecology, Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Shani, M., Institute for Animal Science, The Volcani Center, Bet Dagan, 50250, Israel
Sofer, D., Dept. of Pathology (Neuropathology), Hadassah University Medical Center, Box 12000, Jerusalem, Israel
Embryonic cultures but not embryos transplanted to the mouse's brain grow rapidly without immunosuppression
Embryos and embryocultures can be successfully transplanted into various bodily organs. However, immunosuppression or homogenicity are required for the success of such experimental manipulation. Since the brain is considered immunologically privileged, we transplanted 2-4 cell embryos of C57BL x BALB/c, embryonic stem cells (ES) or embryoid bodies (EB) cultures into the hippocampus of the heterogeneous mouse stock HSMBg. Both ES and EB cultures developed into an extensive growth, eventually larger than the brain itself, causing the death of the host in less than 29 days. The growth was identified as teratoma, mostly made of immature cells and tissues of diverse origin. Thus, the overall histological picture was that of a malignant teratoma. On the other hand, no embryos were found at any time after the transplantation; apparently, they could not survive in the host brain. The growth rate and the relative lack of rejection suggest that the brain offers a unique medium for ES and EB cultures but, not to embryos. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Scientific Publication
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