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Interactive environmental and genetic effects on longevity in the male rat: Litter size, exercise, electric shocks and castration
Year:
1986
Source of publication :
Experimental Aging Research
Authors :
דרורי, דוד
;
.
פולמן, ישעיהו
;
.
Volume :
12
Co-Authors:
Drori, D., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet Dagan, 50-250, Israel
Folman, Y., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet Dagan, 50-250, Israel
Facilitators :
From page:
59
To page:
64
(
Total pages:
6
)
Abstract:
The effects on longevity of manipulating litter size during rearing and of postweaning forced exercise were observed in intact and castrated male rats. Random-bred sib quintets of newborn littermates were reared in reduced litters or normal litters (5 or 6, or 10-12 young, respectively). The quintets were split into five postweaning treatments: (a) untreated (control), (b) exer cised (forced to run by electric shocks), (c) shocked (without exercise), (d) castrated, and (e) castrated and exercised. Reduced litter size increased weaning weight from 46 to 56 g and diminished mean longevity from 724 to 620 days. The decrease in longevity due to reduced litter size was greater in the control (204 days) than in the other postweaning treatments (42 to 142 days). The postweaning treatments affected longevity only in the reduced-litter males; in these, exercise and mere shocks appeared to increase longevity. The variation in longevity among quintets was large and the expression of genetic longevity interacted with the treatments. The regression of individual on mean sib longevity was.89 in the castrates but only.10 in the controls; in exercised and shocked males it was.58 in normal-litter but only.09 in reduced-litter sibs indicating an interaction between pre- and postweaning treatments. The implications of the results on the interpretation of longevity studies are discussed. © 1986 Taylor & Francis Group, LLC.
Note:
Related Files :
adipose tissue
Animal
animal experiment
castration
eating
Electroshock
endocrine system
exercise
Male
Random Allocation
עוד תגיות
תוכן קשור
More details
DOI :
10.1080/03610738608259437
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26109
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:20
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Scientific Publication
Interactive environmental and genetic effects on longevity in the male rat: Litter size, exercise, electric shocks and castration
12
Drori, D., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet Dagan, 50-250, Israel
Folman, Y., Institute of Animal Science, Agricultural Research Organization, The Volcani Center, P.O. Box 6, Bet Dagan, 50-250, Israel
Interactive environmental and genetic effects on longevity in the male rat: Litter size, exercise, electric shocks and castration
The effects on longevity of manipulating litter size during rearing and of postweaning forced exercise were observed in intact and castrated male rats. Random-bred sib quintets of newborn littermates were reared in reduced litters or normal litters (5 or 6, or 10-12 young, respectively). The quintets were split into five postweaning treatments: (a) untreated (control), (b) exer cised (forced to run by electric shocks), (c) shocked (without exercise), (d) castrated, and (e) castrated and exercised. Reduced litter size increased weaning weight from 46 to 56 g and diminished mean longevity from 724 to 620 days. The decrease in longevity due to reduced litter size was greater in the control (204 days) than in the other postweaning treatments (42 to 142 days). The postweaning treatments affected longevity only in the reduced-litter males; in these, exercise and mere shocks appeared to increase longevity. The variation in longevity among quintets was large and the expression of genetic longevity interacted with the treatments. The regression of individual on mean sib longevity was.89 in the castrates but only.10 in the controls; in exercised and shocked males it was.58 in normal-litter but only.09 in reduced-litter sibs indicating an interaction between pre- and postweaning treatments. The implications of the results on the interpretation of longevity studies are discussed. © 1986 Taylor & Francis Group, LLC.
Scientific Publication
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