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פותח על ידי קלירמאש פתרונות בע"מ -
Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis
Year:
2006
Source of publication :
Journal of Infection
Authors :
סיונוב, אדוארד
;
.
Volume :
53
Co-Authors:
Sionov, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978, Israel
Mendlovic, S., Institute of Pathology, Assaf Harofe Medical Center, Zerifin, Israel
Segal, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978, Israel
Facilitators :
From page:
131
To page:
139
(
Total pages:
9
)
Abstract:
Objective: Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was to evaluate the efficacy of combination treatment consisting of the polyene amphotericin B (AMB) or amphotericin B-intralipid admixture (AMB-IL) and the echinocandin caspofungin (CAS) in experimental murine systemic aspergillosis. Inhibition of synthesis of a major component of the fungal cell wall and an effect on the cell membrane, by combining echinocandin and a polyene, may result in a synergistic interaction in vitro and in vivo against Aspergillus fumigatus. Methods: ICR mice were immunosuppressed by intraperitoneal (ip) administration of cyclophosphamide (CY). Three days post-CY administration the mice were inoculated intravenously (iv) with A. fumigatus conidia. Infection and treatment were evaluated during an observation period of 30 days in terms of mortality (survival rate and mean survival time) and morbidity (quantitative determination of fungal burden, histopathology, and detection of serum galactomannan). Results: The data showed that combined CAS and AMB or AMB-IL treatment increased the survival of the mice (up to 69.2%) as compared to those treated with each agent alone (44.4, 40.7 and 50%, respectively), and prolonged their mean survival time to 22.5 days. These combinations also resulted in reduction of fungal burden in organs, and decrease in serum galactomannan. Conclusion: The successful results obtained in the experimental animal model of this study may possibly open the way to more effective management of aspergillosis in humans. © 2005 The British Infection Society.
Note:
Related Files :
amphotericin B
amphotericin B lipid complex
animal experiment
Animals
Female
mice
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.jinf.2005.10.015
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26202
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:20
Scientific Publication
Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis
53
Sionov, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978, Israel
Mendlovic, S., Institute of Pathology, Assaf Harofe Medical Center, Zerifin, Israel
Segal, E., Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, 69978, Israel
Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experimental aspergillosis
Objective: Infections caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. The objective of this study was to evaluate the efficacy of combination treatment consisting of the polyene amphotericin B (AMB) or amphotericin B-intralipid admixture (AMB-IL) and the echinocandin caspofungin (CAS) in experimental murine systemic aspergillosis. Inhibition of synthesis of a major component of the fungal cell wall and an effect on the cell membrane, by combining echinocandin and a polyene, may result in a synergistic interaction in vitro and in vivo against Aspergillus fumigatus. Methods: ICR mice were immunosuppressed by intraperitoneal (ip) administration of cyclophosphamide (CY). Three days post-CY administration the mice were inoculated intravenously (iv) with A. fumigatus conidia. Infection and treatment were evaluated during an observation period of 30 days in terms of mortality (survival rate and mean survival time) and morbidity (quantitative determination of fungal burden, histopathology, and detection of serum galactomannan). Results: The data showed that combined CAS and AMB or AMB-IL treatment increased the survival of the mice (up to 69.2%) as compared to those treated with each agent alone (44.4, 40.7 and 50%, respectively), and prolonged their mean survival time to 22.5 days. These combinations also resulted in reduction of fungal burden in organs, and decrease in serum galactomannan. Conclusion: The successful results obtained in the experimental animal model of this study may possibly open the way to more effective management of aspergillosis in humans. © 2005 The British Infection Society.
Scientific Publication
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