חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate
Year:
2009
Source of publication :
Journal of Animal Science
Authors :
דן, הראל
;
.
חסדאי, אהרון
;
.
Volume :
87
Co-Authors:
Dan, H., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel, Institute of Animal Science, The Volcani Center, Bet Dagan, 50200, Israel
Simsa-Maziel, S., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Hisdai, A., Institute of Animal Science, The Volcani Center, Bet Dagan, 50200, Israel
Sela-Donenfeld, D., Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Monsonego Ornan, E., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Facilitators :
From page:
3544
To page:
3555
(
Total pages:
12
)
Abstract:
Tibial dyschondroplasia (TD) is a prevalent skeletal abnormality associated with rapid growth rate in many avian species. It is characterized by the presence of a nonvascularized, nonmineralized lesion that extends from the epiphyseal growth plate into the metaphysis of the proximal tibiotarsal bones. In this study, we examined the expression of 4 members of the matrix metalloproteinase (MMP) family (MMP-2, -3, -9, and -13) in thiram-induced TD lesions and in the process of recovery from TD, by in situ hybridization analysis and quantitative real-time PCR. A model for the induction and recovery of TD was established, consisting of 3 groups of broilers: (1) thiram group, chicks fed a thiram-enriched diet to induce TD; (2) recovery group, chicks fed a thiram-enriched diet during the first week of the experiment and a normal diet from the sec-ond week on; and (3) control group, chicks fed a normal diet throughout the experimental period. In agreement with our previous data, the 4 MMP were diminished in the TD lesion (P < 0.05); however, in the current study we show that the growth plate was able to repair itself and that the MMP reappeared during the process of recovery from TD. Our results strengthen the link be-tween MMP expression and growth-plate impairment, and we suggest that gelatinase activity (MMP-2 and 9) facilitates this process. © 2009 American Society of Animal Science.
Note:
Related Files :
Animal
Animals
biosynthesis
Growth, Development and Aging
Growth plate
Osteochondrodysplasias
עוד תגיות
תוכן קשור
More details
DOI :
10.2527/jas.2009-2068
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26223
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:21
Scientific Publication
Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate
87
Dan, H., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel, Institute of Animal Science, The Volcani Center, Bet Dagan, 50200, Israel
Simsa-Maziel, S., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Hisdai, A., Institute of Animal Science, The Volcani Center, Bet Dagan, 50200, Israel
Sela-Donenfeld, D., Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Monsonego Ornan, E., Department of Biochemistry and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, 76100, Israel
Expression of matrix metalloproteinases during impairment and recovery of the avian growth plate
Tibial dyschondroplasia (TD) is a prevalent skeletal abnormality associated with rapid growth rate in many avian species. It is characterized by the presence of a nonvascularized, nonmineralized lesion that extends from the epiphyseal growth plate into the metaphysis of the proximal tibiotarsal bones. In this study, we examined the expression of 4 members of the matrix metalloproteinase (MMP) family (MMP-2, -3, -9, and -13) in thiram-induced TD lesions and in the process of recovery from TD, by in situ hybridization analysis and quantitative real-time PCR. A model for the induction and recovery of TD was established, consisting of 3 groups of broilers: (1) thiram group, chicks fed a thiram-enriched diet to induce TD; (2) recovery group, chicks fed a thiram-enriched diet during the first week of the experiment and a normal diet from the sec-ond week on; and (3) control group, chicks fed a normal diet throughout the experimental period. In agreement with our previous data, the 4 MMP were diminished in the TD lesion (P < 0.05); however, in the current study we show that the growth plate was able to repair itself and that the MMP reappeared during the process of recovery from TD. Our results strengthen the link be-tween MMP expression and growth-plate impairment, and we suggest that gelatinase activity (MMP-2 and 9) facilitates this process. © 2009 American Society of Animal Science.
Scientific Publication
נגישות
menu      
You may also be interested in