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פותח על ידי קלירמאש פתרונות בע"מ -
The dual function of nitrite under stomach conditions is modulated by reducing compounds
Year:
2009
Source of publication :
Free Radical Biology and Medicine
Authors :
גרניט, רינה
;
.
וולק, יוליה
;
.
קנר, יוסף
;
.
Volume :
47
Co-Authors:
Volk, J., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Gorelik, S., Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
Granit, R., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Kohen, R., Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
Kanner, J., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Facilitators :
From page:
496
To page:
502
(
Total pages:
7
)
Abstract:
Salivary nitrite plays a role in the lipid peroxidation process of muscle tissue in simulated gastric fluid. The objectives of our study were to elucidate the fate of nitrite in the presence of reducing compounds and to evaluate its effect on lipid peroxidation during digestion. Nitrite at pH 3 (possibly NO2{radical dot}, not NO{radical dot}) can oxidize β-carotene, but the addition of reducing compounds, ascorbic acid or polyphenols, alters its effect. Ascorbic acid alone promoted the formation of NO{radical dot} from nitrite only up to pH 3, but the addition of iron ions facilitated the formation of NO{radical dot} up to pH 5.5. NO{radical dot} prevented membranal lipid peroxidation under stomach conditions. Nitrite, only in the presence of reducing compounds, achieved the same goal but at much higher concentrations. Addition of polyphenols to nitrite synergistically improved its antioxidant effect. Therefore, to promote NO{radical dot} production and to achieve better control of the lipid peroxidation process in the stomach, a nitrite-rich meal should be consumed simultaneously with food rich in polyphenols. © 2009.
Note:
Related Files :
Animals
animal tissue
flavonoids
food composition
free radicals
meat
pH
phenols
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.freeradbiomed.2009.04.012
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26231
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:21
You may also be interested in
Scientific Publication
The dual function of nitrite under stomach conditions is modulated by reducing compounds
47
Volk, J., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Gorelik, S., Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
Granit, R., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Kohen, R., Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel
Kanner, J., Department of Food Science, ARO, The Volcani Center, Bet Dagan, 50250, Israel
The dual function of nitrite under stomach conditions is modulated by reducing compounds
Salivary nitrite plays a role in the lipid peroxidation process of muscle tissue in simulated gastric fluid. The objectives of our study were to elucidate the fate of nitrite in the presence of reducing compounds and to evaluate its effect on lipid peroxidation during digestion. Nitrite at pH 3 (possibly NO2{radical dot}, not NO{radical dot}) can oxidize β-carotene, but the addition of reducing compounds, ascorbic acid or polyphenols, alters its effect. Ascorbic acid alone promoted the formation of NO{radical dot} from nitrite only up to pH 3, but the addition of iron ions facilitated the formation of NO{radical dot} up to pH 5.5. NO{radical dot} prevented membranal lipid peroxidation under stomach conditions. Nitrite, only in the presence of reducing compounds, achieved the same goal but at much higher concentrations. Addition of polyphenols to nitrite synergistically improved its antioxidant effect. Therefore, to promote NO{radical dot} production and to achieve better control of the lipid peroxidation process in the stomach, a nitrite-rich meal should be consumed simultaneously with food rich in polyphenols. © 2009.
Scientific Publication
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