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פותח על ידי קלירמאש פתרונות בע"מ -
Delayed effect of low progesterone concentrations on bovine uterine PGF2α secretion in the subsequent oestrous cycle
Year:
2001
Source of publication :
Reproduction
Authors :
פולמן, ישעיהו
;
.
קאים, משה
;
.
Volume :
122
Co-Authors:
Shaham-Albalancy, A., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Folman, Y., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Kaim, M., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Rosenberg, M., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Wolfenson, D., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Facilitators :
From page:
643
To page:
648
(
Total pages:
6
)
Abstract:
Low progesterone concentrations during the bovine oestrous cycle induce enhanced responsiveness to oxytocin challenge late in the luteal phase of the same cycle. The delayed effect of low progesterone concentrations during one oestrous cycle on uterine PGF2α secretion after oxytocin challenge on day 15 or 16 of the subsequent cycle was studied by measuring the concentrations of the major PGF2α metabolite (13,14-dihydro-15-keto PGF2α; PGFM) in plasma. Two experiments were conducted, differing in the type of progesterone treatment and in the shape of the low progesterone concentration curves. In Expt 1, progesterone supplementation with intravaginal progesterone inserts, with or without an active corpus luteum, was used to obtain high, or low and constant plasma progesterone concentrations, respectively. In Expt 2, untreated cows, representing high progesterone treatment, were compared with cows that had low but increasing plasma progesterone concentrations that were achieved by manipulating endogenous progesterone secretion of the corpus luteum. Neither experiment revealed any differences in plasma progesterone concentrations between the high and low progesterone groups in the subsequent oestrous cycle. In both experiments, both groups had similar basal concentrations of PGFM on day 15 (Expt 1) or 16 (Expt 2) of the subsequent oestrous cycle, 18 days after progesterone treatments had ended. In both experiments, the increases in PGFM concentrations in the low progesterone groups after an oxytocin challenge were markedly higher than in the high progesterone groups. These results indicate that low progesterone concentrations during an oestrous cycle have a delayed stimulatory effect on uterine responsiveness to oxytocin during the late luteal phase of the subsequent cycle. This resulting increase in PGF2α secretion may interfere with luteal maintenance during the early stages of pregnancy.
Note:
Related Files :
animal experiment
Animals
cattle
corpus luteum
Estrus Synchronization
Female
pregnancy
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26262
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:21
You may also be interested in
Scientific Publication
Delayed effect of low progesterone concentrations on bovine uterine PGF2α secretion in the subsequent oestrous cycle
122
Shaham-Albalancy, A., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Folman, Y., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Kaim, M., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Rosenberg, M., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Wolfenson, D., Department of Animal Science, Faculty of Agricultural, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Delayed effect of low progesterone concentrations on bovine uterine PGF2α secretion in the subsequent oestrous cycle
Low progesterone concentrations during the bovine oestrous cycle induce enhanced responsiveness to oxytocin challenge late in the luteal phase of the same cycle. The delayed effect of low progesterone concentrations during one oestrous cycle on uterine PGF2α secretion after oxytocin challenge on day 15 or 16 of the subsequent cycle was studied by measuring the concentrations of the major PGF2α metabolite (13,14-dihydro-15-keto PGF2α; PGFM) in plasma. Two experiments were conducted, differing in the type of progesterone treatment and in the shape of the low progesterone concentration curves. In Expt 1, progesterone supplementation with intravaginal progesterone inserts, with or without an active corpus luteum, was used to obtain high, or low and constant plasma progesterone concentrations, respectively. In Expt 2, untreated cows, representing high progesterone treatment, were compared with cows that had low but increasing plasma progesterone concentrations that were achieved by manipulating endogenous progesterone secretion of the corpus luteum. Neither experiment revealed any differences in plasma progesterone concentrations between the high and low progesterone groups in the subsequent oestrous cycle. In both experiments, both groups had similar basal concentrations of PGFM on day 15 (Expt 1) or 16 (Expt 2) of the subsequent oestrous cycle, 18 days after progesterone treatments had ended. In both experiments, the increases in PGFM concentrations in the low progesterone groups after an oxytocin challenge were markedly higher than in the high progesterone groups. These results indicate that low progesterone concentrations during an oestrous cycle have a delayed stimulatory effect on uterine responsiveness to oxytocin during the late luteal phase of the subsequent cycle. This resulting increase in PGF2α secretion may interfere with luteal maintenance during the early stages of pregnancy.
Scientific Publication
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