חיפוש מתקדם
תחביר
חפש...
הספר "אוצר וולקני"
אודות
תנאי שימוש
ניהול
קהילה:
אסיף מאגר המחקר החקלאי
פותח על ידי קלירמאש פתרונות בע"מ -
Rationally designed neuropeptide antagonists: A novel approach for generation of environmentally friendly insecticides
Year:
1997
Source of publication :
Invertebrate Neuroscience
Authors :
אלטשטיין, מרים
;
.
בן-עזיז, אורנה
;
.
דניאל, שי
;
.
שפלר, אירית
;
.
Volume :
3
Co-Authors:
Gilon, C., Department of Organic Chemistry, Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Zeltser, I., Department of Organic Chemistry, Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Daniel, S., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Ben-Aziz, O., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Schefler, I., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Altstein, M., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Facilitators :
From page:
245
To page:
250
(
Total pages:
6
)
Abstract:
We report our approach for the generation of a novel type of putative insecticides based on backbone cyclic peptidomimetic antagonists of insect neuropeptides using pheromone biosynthesis activating neuropeptide (PBAN) as a model. This approach, called the backbone cyclic neuropeptide based antagonist (BBC-NBA), includes the following steps: (i) elucidation of the active sequence of the chosen insect neuropeptide; (ii) disclosure of a lead antagonist based on the sequence found in step (i); (iii) design and synthesis of backbone cyclic peptide libraries (cycloscan) based on the sequence of the lead antagonist; and (iv) design and synthesis of a peptidomimetic prototype insecticide. The BBC-NBA approach was applied to PBAN and led to the discovery of a potent linear lead antagonist and a potent backbone cyclic antagonist devoid of agonistic activity which inhibited sex pheromone biosynthesis in Heliothis peltigera female moths.
Note:
Related Files :
Conference paper
environmental health
Heliothis peltigera
hormone synthesis
insecticide
neuropeptide
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/BF02480381
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר מתוך כינוס
;
.
Language:
אנגלית
Editors' remarks:
ID:
26336
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:21
You may also be interested in
Scientific Publication
Rationally designed neuropeptide antagonists: A novel approach for generation of environmentally friendly insecticides
3
Gilon, C., Department of Organic Chemistry, Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Zeltser, I., Department of Organic Chemistry, Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Daniel, S., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Ben-Aziz, O., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Schefler, I., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Altstein, M., Department of Entomology, Volcani Center for Agricultural Research, Bet Dagan 50250, Israel
Rationally designed neuropeptide antagonists: A novel approach for generation of environmentally friendly insecticides
We report our approach for the generation of a novel type of putative insecticides based on backbone cyclic peptidomimetic antagonists of insect neuropeptides using pheromone biosynthesis activating neuropeptide (PBAN) as a model. This approach, called the backbone cyclic neuropeptide based antagonist (BBC-NBA), includes the following steps: (i) elucidation of the active sequence of the chosen insect neuropeptide; (ii) disclosure of a lead antagonist based on the sequence found in step (i); (iii) design and synthesis of backbone cyclic peptide libraries (cycloscan) based on the sequence of the lead antagonist; and (iv) design and synthesis of a peptidomimetic prototype insecticide. The BBC-NBA approach was applied to PBAN and led to the discovery of a potent linear lead antagonist and a potent backbone cyclic antagonist devoid of agonistic activity which inhibited sex pheromone biosynthesis in Heliothis peltigera female moths.
Scientific Publication
נגישות
menu      
You may also be interested in