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פותח על ידי קלירמאש פתרונות בע"מ -
Undifferentiated leukemia of infancy with t(11:17) chromosomal rearrangement. Coexpressing myeloid and B cell restricted antigens
Year:
1987
Source of publication :
Cancer
Authors :
קציר, נורית
;
.
Volume :
59
Co-Authors:
Umiel, T., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Nadler, L.M., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Cohen, I.J., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Levine, H.
Stark, B.
Mammon, Z.
Dzaldetti, M.
Rechavi, G.
Simoni, F.
Katzir, N.
Facilitators :
From page:
1143
To page:
1149
(
Total pages:
7
)
Abstract:
It has been suggested that the malignant transformation, in some of the acute leukemias, may involve totipotent stem cells resulting in a biphenotypic leukemia expressing both myeloid, and lymphoid characteristics. We describe here a hybrid cell acute leukemia, in a 16-day-old infant, in whom leukemic cells coexpressed myeloid and lymphoid B cell antigens. Blast cells in the bone marrow showed L2 morphology according to the French American British (FAB) classification, with positive periodic-acid Schiff, and nonspecific esterase staining. Sudan black, and specific esterase were negative. Terminal deoxynucleotidyl transferase, was strongly positive in 5% of blasts, and faintly reactive with the rest. Karyotypic analysis demonstrated a translocation of t(11:17);(q23;p13). Immunoglobulin gene analysis revealed rearrangement of the heavy chain genes. The blasts' phenotype was HLA/DR+ B4+ My7+ My9+ common acute lymphoblastic leukemia antigen (CALLA) B1- T11-. Dual immunofluorescence staining using anti My7, and My9 fluorescein isothiocyanate, and anti B4 pycoerythrin conjugated monoclonal antibodies, and flow cytofluorometry, revealed a labeling pattern of 25% B4+; 10% to 15% My7+; 17% My9+; and 50% of cells coexpressing B4 My7, and My9 antigens. These results provide evidence for a hybrid leukemia with lymphomyeloblasts being part of a single clone, which may indicate the origin of this leukemic clone from a pluripotent (lymphoid/myeloid) stem cell.
Note:
Related Files :
Antibodies, Monoclonal
genetic engineering
Heredity
Leukemia
Tumor Stem Cells
עוד תגיות
תוכן קשור
More details
DOI :
10.1002/1097-0142(19870315)59:6<1143::AID-CNCR2820590618>3.0.CO;2-J
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26399
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:22
You may also be interested in
Scientific Publication
Undifferentiated leukemia of infancy with t(11:17) chromosomal rearrangement. Coexpressing myeloid and B cell restricted antigens
59
Umiel, T., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Nadler, L.M., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Cohen, I.J., Pediatric Hematology/Oncology, Beilinson Medical Center, Petach Tikva 49100, Israel
Levine, H.
Stark, B.
Mammon, Z.
Dzaldetti, M.
Rechavi, G.
Simoni, F.
Katzir, N.
Undifferentiated leukemia of infancy with t(11:17) chromosomal rearrangement. Coexpressing myeloid and B cell restricted antigens
It has been suggested that the malignant transformation, in some of the acute leukemias, may involve totipotent stem cells resulting in a biphenotypic leukemia expressing both myeloid, and lymphoid characteristics. We describe here a hybrid cell acute leukemia, in a 16-day-old infant, in whom leukemic cells coexpressed myeloid and lymphoid B cell antigens. Blast cells in the bone marrow showed L2 morphology according to the French American British (FAB) classification, with positive periodic-acid Schiff, and nonspecific esterase staining. Sudan black, and specific esterase were negative. Terminal deoxynucleotidyl transferase, was strongly positive in 5% of blasts, and faintly reactive with the rest. Karyotypic analysis demonstrated a translocation of t(11:17);(q23;p13). Immunoglobulin gene analysis revealed rearrangement of the heavy chain genes. The blasts' phenotype was HLA/DR+ B4+ My7+ My9+ common acute lymphoblastic leukemia antigen (CALLA) B1- T11-. Dual immunofluorescence staining using anti My7, and My9 fluorescein isothiocyanate, and anti B4 pycoerythrin conjugated monoclonal antibodies, and flow cytofluorometry, revealed a labeling pattern of 25% B4+; 10% to 15% My7+; 17% My9+; and 50% of cells coexpressing B4 My7, and My9 antigens. These results provide evidence for a hybrid leukemia with lymphomyeloblasts being part of a single clone, which may indicate the origin of this leukemic clone from a pluripotent (lymphoid/myeloid) stem cell.
Scientific Publication
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