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פותח על ידי קלירמאש פתרונות בע"מ -
Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: Health implications
Year:
2005
Authors :
גרניט, רינה
;
.
קנר, יוסף
;
.
שחם, ענבל
;
.
Volume :
53
Co-Authors:
Gorelik, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lapidot, T., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Shaham, I., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Granit, R., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Ligumsky, M., Gastroenterology Unit, Hadassah University Hospital, Jerusalem 91120, Israel
Kohen, R., Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem 91120, Israel
Kanner, J., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
3397
To page:
3402
(
Total pages:
6
)
Abstract:
The Western diet contains large quantities of oxidized lipids, because a large proportion of the food in the diet is consumed in a fried, heated, processed, or stored form. We investigated the reaction that could occur in the acidic pH of the stomach and accelerate the generation of lipid hydroperoxides and cooxidation of dietary vitamins. To estimate the oxygen content in the stomach after food consumption, oxygen released from masticated bread (20 g) into deoxygenated water (100 mL) was measured. Under these conditions, the oxygen concentration rose by 250 μM and reached a full oxygen saturation. The present study demonstrated that heated red meat homogenized in human gastric fluid, at pH 3.0, generated hydroperoxides and malondialdehyde. The cross-reaction between free radicals produced during this reaction cooxidized vitamin E, β-carotene, and vitamin C. Both lipid peroxidation and cooxidation of vitamin E and β-carotene were inhibited at pH 3.0 by red wine polyphenols. Ascorbic acid (44 mg) at a concentration that represented the amount that could be ingested during a meal inhibited lipid peroxidation only slightly. Red wine polyphenols failed to prevent ascorbic acid oxidation significantly but, in conjunction with ascorbic acid, did inhibit lipid peroxidation. In the presence of catechin, a well-known polyphenol found in red wine, ascorbic acid at pH 3.0 works in a synergistic manner preventing lipid peroxidation and β-carotene cooxidation. The present data may explain the major benefits to our health and the crucial role of consuming food products rich in dietary antioxidants such as fruits, vegetables, red wines, or green tea during the meal. © 2005 American Chemical Society.
Note:
Related Files :
Animal
Animals
antioxidants
flavonoids
Human gastric fluid
meat
pH
phenols
vitamins
עוד תגיות
תוכן קשור
More details
DOI :
10.1021/jf040401o
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26414
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:22
Scientific Publication
Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: Health implications
53
Gorelik, S., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lapidot, T., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Shaham, I., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Granit, R., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Ligumsky, M., Gastroenterology Unit, Hadassah University Hospital, Jerusalem 91120, Israel
Kohen, R., Department of Pharmacology, School of Pharmacy, Hebrew University, Jerusalem 91120, Israel
Kanner, J., Department of Food Science, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: Health implications
The Western diet contains large quantities of oxidized lipids, because a large proportion of the food in the diet is consumed in a fried, heated, processed, or stored form. We investigated the reaction that could occur in the acidic pH of the stomach and accelerate the generation of lipid hydroperoxides and cooxidation of dietary vitamins. To estimate the oxygen content in the stomach after food consumption, oxygen released from masticated bread (20 g) into deoxygenated water (100 mL) was measured. Under these conditions, the oxygen concentration rose by 250 μM and reached a full oxygen saturation. The present study demonstrated that heated red meat homogenized in human gastric fluid, at pH 3.0, generated hydroperoxides and malondialdehyde. The cross-reaction between free radicals produced during this reaction cooxidized vitamin E, β-carotene, and vitamin C. Both lipid peroxidation and cooxidation of vitamin E and β-carotene were inhibited at pH 3.0 by red wine polyphenols. Ascorbic acid (44 mg) at a concentration that represented the amount that could be ingested during a meal inhibited lipid peroxidation only slightly. Red wine polyphenols failed to prevent ascorbic acid oxidation significantly but, in conjunction with ascorbic acid, did inhibit lipid peroxidation. In the presence of catechin, a well-known polyphenol found in red wine, ascorbic acid at pH 3.0 works in a synergistic manner preventing lipid peroxidation and β-carotene cooxidation. The present data may explain the major benefits to our health and the crucial role of consuming food products rich in dietary antioxidants such as fruits, vegetables, red wines, or green tea during the meal. © 2005 American Chemical Society.
Scientific Publication
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