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פותח על ידי קלירמאש פתרונות בע"מ -
The Regulation of Dictyostelium Development by Transmembrane Signalling
Year:
1995
Source of publication :
Journal of Eukaryotic Microbiology
Authors :
גולופ, רחל
;
.
Volume :
42
Co-Authors:
GINSBURG, G.T., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
GOLLOP, R., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
YU, Y., Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322, United States
LOUIS, J.M., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
SAXE, C.L., Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322, United States
KIMMEL, A.R., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
Facilitators :
From page:
200
To page:
205
(
Total pages:
6
)
Abstract:
ABSTRACT. Dictyostelium discoideum has a well characterized life cycle where unicellular growth and multicellular development are separated events. Development is dependent upon signal transduction mediated by cell surface, cAMP receptor/G protein linkages. Secreted cAMP acts extracellularly as a primary signal and chemoattractant. There are 4 genes for the distinct cAMP receptor subtypes, CAR1, CAR2, CAR3 and CAR4. These subtypes are expressed with temporally and spatially specific patterns and cells carrying null mutations for each gene have distinct developmental phenotypes. These results indicate an essential role for cAMP signalling throughout Dictyostelium development to regulate such diverse pathways as cell motility, aggregation (multicellularity), cytodifferentiation, pattern formation and cell type‐specific gene expression. Copyright © 1995, Wiley Blackwell. All rights reserved
Note:
Related Files :
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Differentiation
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Growth, Development and Aging
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Receptors
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1550-7408.1995.tb01565.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26718
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:24
You may also be interested in
Scientific Publication
The Regulation of Dictyostelium Development by Transmembrane Signalling
42
GINSBURG, G.T., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
GOLLOP, R., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
YU, Y., Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322, United States
LOUIS, J.M., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
SAXE, C.L., Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322, United States
KIMMEL, A.R., Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bldg 6/B1-22, Bethesda, Maryland, 20892, United States
The Regulation of Dictyostelium Development by Transmembrane Signalling
ABSTRACT. Dictyostelium discoideum has a well characterized life cycle where unicellular growth and multicellular development are separated events. Development is dependent upon signal transduction mediated by cell surface, cAMP receptor/G protein linkages. Secreted cAMP acts extracellularly as a primary signal and chemoattractant. There are 4 genes for the distinct cAMP receptor subtypes, CAR1, CAR2, CAR3 and CAR4. These subtypes are expressed with temporally and spatially specific patterns and cells carrying null mutations for each gene have distinct developmental phenotypes. These results indicate an essential role for cAMP signalling throughout Dictyostelium development to regulate such diverse pathways as cell motility, aggregation (multicellularity), cytodifferentiation, pattern formation and cell type‐specific gene expression. Copyright © 1995, Wiley Blackwell. All rights reserved
Scientific Publication
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