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פותח על ידי קלירמאש פתרונות בע"מ -
Topical treatment of cutaneous chronic graft versus host disease with halofuginone: A novel inhibitor of collagen type I synthesis
Year:
1999
Source of publication :
Transplantation
Authors :
פינס, מרק
;
.
Volume :
68
Co-Authors:
Nagler, A., Dept. of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Institute of Animal Science, ARO, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
1806
To page:
1809
(
Total pages:
4
)
Abstract:
Background. In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen α1(I) gene expression. Methods. Halofuginone-containing ointment was applied daily on the left side of the neck and shoulder of a cGvHD patient. Collagen α1(I) gene expression and collagen content in skin biopsy specimens were evaluated by in situ hybridization and sirius red staining, respectively. Results. After 3 and 6 months, a marked reduction in skin collagen synthesis was observed, accompanied with increase neck rotation on the treated side. After cessation of treatment, the sclerosis, skin tightness, and collagen α1(I) gene expression returned to baseline level. No adverse effects were observed, and no plasma levels of halofuginone could be detected. Conclusions. Halofuginone may provide a promising novel and safe therapy for cGvHD patients.
Note:
Related Files :
adult
Animals
Drug Safety
gene expression
graft versus host reaction
Graft vs Host Disease
Male
Rabbits
skin fibrosis
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26772
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:25
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Scientific Publication
Topical treatment of cutaneous chronic graft versus host disease with halofuginone: A novel inhibitor of collagen type I synthesis
68
Nagler, A., Dept. of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel
Pines, M., Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel, Institute of Animal Science, ARO, Volcani Center, Bet Dagan 50250, Israel
Topical treatment of cutaneous chronic graft versus host disease with halofuginone: A novel inhibitor of collagen type I synthesis
Background. In chronic graft-versus-host disease (cGvHD), skin fibrosis, contractures, and an increase in collagen content form the hallmark. We report a successful treatment of a cGvHD patient by topical application of halofuginone, an inhibitor of collagen α1(I) gene expression. Methods. Halofuginone-containing ointment was applied daily on the left side of the neck and shoulder of a cGvHD patient. Collagen α1(I) gene expression and collagen content in skin biopsy specimens were evaluated by in situ hybridization and sirius red staining, respectively. Results. After 3 and 6 months, a marked reduction in skin collagen synthesis was observed, accompanied with increase neck rotation on the treated side. After cessation of treatment, the sclerosis, skin tightness, and collagen α1(I) gene expression returned to baseline level. No adverse effects were observed, and no plasma levels of halofuginone could be detected. Conclusions. Halofuginone may provide a promising novel and safe therapy for cGvHD patients.
Scientific Publication
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