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פותח על ידי קלירמאש פתרונות בע"מ -
The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion
Year:
1997
Source of publication :
Planta Medica
Authors :
פלביץ', דן
;
.
Volume :
63
Co-Authors:
Vered, Y., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Grosskopf, I., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Palevitch, D., Department of Plant Genetics, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Harsat, A., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Charach, G., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Weintraub, M.S., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Graff, E., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Facilitators :
From page:
237
To page:
240
(
Total pages:
4
)
Abstract:
Dopamine (DA) is known to increase diuresis and natriuresis through its action on renal dopaminergic receptors. Augmentation of intra-renal DA concentration by enhancement of its in situ production is greatly dependent on the availability of its precursor L-DOPA to the sites of its renal decarboxylation. Vicia faba (Vf) is a ubiquitous plant rich in easily absorbable L-DOPA. Following ingestion of 40g freshly chopped Vf containing 120-130mg of L-DOPA, plasma L-DOPA and urinary sodium and DA excretion increased significantly. The DA/Cre ratio reached a maximum level (280 ± 58μg/g) 60 minutes after Vf ingestion. This was significantly higher than the DA/Cre ratio after a control meal (1.8 ± 0.2μg/g; P < 0.0005). The Na/Cre ratio reached the maximal level (2.85 ± 0.42mmol/g) 90 minutes after Vf ingestion. This was significantly higher than the Na/Cre ratio after the control meal (1.4 ± 0.24 mmol/g; P < 0.005). We suggest that Vf might be of value in treating conditions such as hypertension, heart failure, renal failure, and liver cirrhosis in which natriuresis and diuresis are medically beneficial.
Note:
Related Files :
adult
Fabaceae
Female
heart failure
Hypertension
Male
oral drug administration
plant extract
plant seed
Vicia faba
עוד תגיות
תוכן קשור
More details
DOI :
10.1055/s-2006-957661
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26777
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:25
Scientific Publication
The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion
63
Vered, Y., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Grosskopf, I., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Palevitch, D., Department of Plant Genetics, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Harsat, A., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Charach, G., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Weintraub, M.S., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Graff, E., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
The influence of Vicia faba (broad bean) seedlings on urinary sodium excretion
Dopamine (DA) is known to increase diuresis and natriuresis through its action on renal dopaminergic receptors. Augmentation of intra-renal DA concentration by enhancement of its in situ production is greatly dependent on the availability of its precursor L-DOPA to the sites of its renal decarboxylation. Vicia faba (Vf) is a ubiquitous plant rich in easily absorbable L-DOPA. Following ingestion of 40g freshly chopped Vf containing 120-130mg of L-DOPA, plasma L-DOPA and urinary sodium and DA excretion increased significantly. The DA/Cre ratio reached a maximum level (280 ± 58μg/g) 60 minutes after Vf ingestion. This was significantly higher than the DA/Cre ratio after a control meal (1.8 ± 0.2μg/g; P < 0.0005). The Na/Cre ratio reached the maximal level (2.85 ± 0.42mmol/g) 90 minutes after Vf ingestion. This was significantly higher than the Na/Cre ratio after the control meal (1.4 ± 0.24 mmol/g; P < 0.005). We suggest that Vf might be of value in treating conditions such as hypertension, heart failure, renal failure, and liver cirrhosis in which natriuresis and diuresis are medically beneficial.
Scientific Publication
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