Vered, Y., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Grosskopf, I., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Palevitch, D., Department of Plant Genetics, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel
Harsat, A., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Charach, G., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Weintraub, M.S., Department of Internal Medicine C, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Graff, E., Clinical Chemistry Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

Dopamine (DA) is known to increase diuresis and natriuresis through its action on renal dopaminergic receptors. Augmentation of intra-renal DA concentration by enhancement of its in situ production is greatly dependent on the availability of its precursor L-DOPA to the sites of its renal decarboxylation. Vicia faba (Vf) is a ubiquitous plant rich in easily absorbable L-DOPA. Following ingestion of 40g freshly chopped Vf containing 120-130mg of L-DOPA, plasma L-DOPA and urinary sodium and DA excretion increased significantly. The DA/Cre ratio reached a maximum level (280 ± 58μg/g) 60 minutes after Vf ingestion. This was significantly higher than the DA/Cre ratio after a control meal (1.8 ± 0.2μg/g; P < 0.0005). The Na/Cre ratio reached the maximal level (2.85 ± 0.42mmol/g) 90 minutes after Vf ingestion. This was significantly higher than the Na/Cre ratio after the control meal (1.4 ± 0.24 mmol/g; P < 0.005). We suggest that Vf might be of value in treating conditions such as hypertension, heart failure, renal failure, and liver cirrhosis in which natriuresis and diuresis are medically beneficial.