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פותח על ידי קלירמאש פתרונות בע"מ -
The Failure of Long-Term Feeding of Raw Soy Flour, in the Presence or Absence of Azaserine, to Induce Carcinogenic Changes in the Mouse Pancreas
Year:
1986
Source of publication :
Nutrition and Cancer
Authors :
חסדאי, אהרון
;
.
Volume :
8
Co-Authors:
Hasdai, A., Department of Animal Science, Agricultural Research Organization, The Volcani Center, Bet-Dagan, 50250, Israel, Department ot Biochemistry, University of Minnesota, St. Paul, MN, 55108., United States
Facilitators :
From page:
85
To page:
91
(
Total pages:
7
)
Abstract:
The effects of feeding mice raw or heated soy flours or casein in the presence and absence of injected azaserine were investigated over a peiod of 18 months. Although the feeding of raw soy flour (compared with heated soy flour or casein) caused a significant inhibition of growth and an enlargement of the pancreas, there was no macroscopic evidence of pancreatic nodules in any of the six experimental groups. Microscopic examination of the pancreas revealed a somewhat higher (not significant) incidence of atypical acinar cell nodules in all animals injected with azaserine, but this difference was little influenced by the diets themselves. We concluded that raw soy flour itself has no carcinogenic effect on the mouse pancreas and does not enhance the sensitivity of the mouse pancreas to azaserine. Thus, it cannot be assumed that the appearance of pancreatic nodules constitutes an obligatory sequela of pancreatic hypertrophy and/or hyperplasia in all species of animals. © 1986, Taylor & Francis Group, LLC. All rights reserved.
Note:
Related Files :
Animal
azaserine
body weight
eating
mice
organ weight
Pancreas
Support, Non-U.S. Gov't
Time Factors
עוד תגיות
תוכן קשור
More details
DOI :
10.1080/01635588609513880
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26823
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:25
Scientific Publication
The Failure of Long-Term Feeding of Raw Soy Flour, in the Presence or Absence of Azaserine, to Induce Carcinogenic Changes in the Mouse Pancreas
8
Hasdai, A., Department of Animal Science, Agricultural Research Organization, The Volcani Center, Bet-Dagan, 50250, Israel, Department ot Biochemistry, University of Minnesota, St. Paul, MN, 55108., United States
The Failure of Long-Term Feeding of Raw Soy Flour, in the Presence or Absence of Azaserine, to Induce Carcinogenic Changes in the Mouse Pancreas
The effects of feeding mice raw or heated soy flours or casein in the presence and absence of injected azaserine were investigated over a peiod of 18 months. Although the feeding of raw soy flour (compared with heated soy flour or casein) caused a significant inhibition of growth and an enlargement of the pancreas, there was no macroscopic evidence of pancreatic nodules in any of the six experimental groups. Microscopic examination of the pancreas revealed a somewhat higher (not significant) incidence of atypical acinar cell nodules in all animals injected with azaserine, but this difference was little influenced by the diets themselves. We concluded that raw soy flour itself has no carcinogenic effect on the mouse pancreas and does not enhance the sensitivity of the mouse pancreas to azaserine. Thus, it cannot be assumed that the appearance of pancreatic nodules constitutes an obligatory sequela of pancreatic hypertrophy and/or hyperplasia in all species of animals. © 1986, Taylor & Francis Group, LLC. All rights reserved.
Scientific Publication
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