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פותח על ידי קלירמאש פתרונות בע"מ -
Strigolactones: A novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells
Year:
2012
Authors :
קולטאי, חננית
;
.
קפולניק, יורם
;
.
Volume :
134
Co-Authors:
Pollock, C.B., Department of Human Science, Georgetown University, St. Mary's Hall, Washington, DC 20007, United States, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3700 Reservoir Road, NW, Washington, DC 20057, United States
Koltai, H., Department of Ornamental Horticulture, Agricultural Research Organization (ARO), Volcani Center, PO Box 6, 50250 Bet Dagan, Israel
Kapulnik, Y., Department of Field Crops, Natural Resources Institute of Plant Sciences, Agricultural Research Organization (ARO), PO Box 6, 50250 Bet Dagan, Israel
Prandi, C., Department of Chemistry, University Turin, via P. Giuria 7, 10125 Turin, Italy
Yarden, R.I., Department of Human Science, Georgetown University, St. Mary's Hall, Washington, DC 20007, United States, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3700 Reservoir Road, NW, Washington, DC 20057, United States
Facilitators :
From page:
1041
To page:
1055
(
Total pages:
15
)
Abstract:
Several naturally occurring phytohormones have shown enormous potential in the prevention and treatment of variety of different type of cancers. Strigolactones (SLs) are a novel class of plant hormones produced in roots and regulate new above ground shoot branching, by inhibiting self-renewal of undifferentiated meristem cells. Here, we study the effects of six synthetic SL analogs on breast cancer cell lines growth and survival. We show that SL analogs are able to inhibit proliferation and induce apoptosis of breast cancer cells but to a much lesser extent "non-cancer" lines. Given the therapeutic problem of cancer recurrence which ishypothesized to bedueto drug resistant cancer stem cells, we also tested the ability of SL analogs to inhibit the growth of mammosphere cultures that are typically enriched with cancer stem-like cells. We show that SLs are potent inhibitors of self-renewal and survival of breast cancer cell lines grown as mammospheres and even a short exposure leads to irreversible effects on mammosphere dissociation and cell death. Immunoblot analysis revealed that SLs analogs induce activation of the stress response mediated by both P38 and JNK1/2 MAPK modules and inhibits PI3K/AKT activation. Taken together this study indicates that SLs may be promising anticancer agents whose activities may be achieved through modulation of stress and survival signaling pathways. © Springer Science+Business Media, LLC. 2012.
Note:
Related Files :
apoptosis
breast cancer
cancer cell destruction
Cell Proliferation
Female
Proliferation
unclassified drug
עוד תגיות
תוכן קשור
More details
DOI :
10.1007/s10549-012-1992-x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26840
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:25
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Scientific Publication
Strigolactones: A novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells
134
Pollock, C.B., Department of Human Science, Georgetown University, St. Mary's Hall, Washington, DC 20007, United States, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3700 Reservoir Road, NW, Washington, DC 20057, United States
Koltai, H., Department of Ornamental Horticulture, Agricultural Research Organization (ARO), Volcani Center, PO Box 6, 50250 Bet Dagan, Israel
Kapulnik, Y., Department of Field Crops, Natural Resources Institute of Plant Sciences, Agricultural Research Organization (ARO), PO Box 6, 50250 Bet Dagan, Israel
Prandi, C., Department of Chemistry, University Turin, via P. Giuria 7, 10125 Turin, Italy
Yarden, R.I., Department of Human Science, Georgetown University, St. Mary's Hall, Washington, DC 20007, United States, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Center, 3700 Reservoir Road, NW, Washington, DC 20057, United States
Strigolactones: A novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells
Several naturally occurring phytohormones have shown enormous potential in the prevention and treatment of variety of different type of cancers. Strigolactones (SLs) are a novel class of plant hormones produced in roots and regulate new above ground shoot branching, by inhibiting self-renewal of undifferentiated meristem cells. Here, we study the effects of six synthetic SL analogs on breast cancer cell lines growth and survival. We show that SL analogs are able to inhibit proliferation and induce apoptosis of breast cancer cells but to a much lesser extent "non-cancer" lines. Given the therapeutic problem of cancer recurrence which ishypothesized to bedueto drug resistant cancer stem cells, we also tested the ability of SL analogs to inhibit the growth of mammosphere cultures that are typically enriched with cancer stem-like cells. We show that SLs are potent inhibitors of self-renewal and survival of breast cancer cell lines grown as mammospheres and even a short exposure leads to irreversible effects on mammosphere dissociation and cell death. Immunoblot analysis revealed that SLs analogs induce activation of the stress response mediated by both P38 and JNK1/2 MAPK modules and inhibits PI3K/AKT activation. Taken together this study indicates that SLs may be promising anticancer agents whose activities may be achieved through modulation of stress and survival signaling pathways. © Springer Science+Business Media, LLC. 2012.
Scientific Publication
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