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פותח על ידי קלירמאש פתרונות בע"מ -
ShiftDetector: Detection of shift mutations
Year:
2002
Source of publication :
bioinformatics (source)
Authors :
סרוסי, אייל
;
.
רון, מיכה
;
.
Volume :
18
Co-Authors:
Seroussi, E., Institute of Animal Science, Volcani Center, Bet-Dagan 50250, Israel
Ron, M., Institute of Animal Science, Volcani Center, Bet-Dagan 50250, Israel
Kedra, D., Information Systems Department, Burnham Institute, San Diego, CA 92037, United States
Facilitators :
From page:
1137
To page:
1138
(
Total pages:
2
)
Abstract:
Sequencing of a bi-allelic PCR product, which contains an allele with a deletion/insertion mutation results in a superimposed tracefile following the site of this shift mutation. A trace file of this type hampers the use of current computer programs for base calling. ShiftDetector analyses a sequencing trace file in order to discover if it is a superimposed sequence of two molecules that differ in a shift mutation of 1 to 25 bases. The program calculates a probability score for the existence of such a shift and reconstructs the sequence of the original molecule.
Note:
Related Files :
Base Sequence
frameshift mutation
gene expression
gene structure
genetic analysis
Internet
sensitivity and specificity
sequence analysis
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
26934
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:26
You may also be interested in
Scientific Publication
ShiftDetector: Detection of shift mutations
18
Seroussi, E., Institute of Animal Science, Volcani Center, Bet-Dagan 50250, Israel
Ron, M., Institute of Animal Science, Volcani Center, Bet-Dagan 50250, Israel
Kedra, D., Information Systems Department, Burnham Institute, San Diego, CA 92037, United States
ShiftDetector: Detection of shift mutations
Sequencing of a bi-allelic PCR product, which contains an allele with a deletion/insertion mutation results in a superimposed tracefile following the site of this shift mutation. A trace file of this type hampers the use of current computer programs for base calling. ShiftDetector analyses a sequencing trace file in order to discover if it is a superimposed sequence of two molecules that differ in a shift mutation of 1 to 25 bases. The program calculates a probability score for the existence of such a shift and reconstructs the sequence of the original molecule.
Scientific Publication
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