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פותח על ידי קלירמאש פתרונות בע"מ -
Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry
Year:
1988
Source of publication :
Skin Pharmacology and Physiology
Authors :
עזרא, דוד
;
.
Volume :
1
Co-Authors:
Peck, C.C., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Conner, D.P., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bolden, B.J., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Almirez, R.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kingsley, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Mell, L.D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Murphy, M.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Hill, V.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Rowland, L.M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Ezra, D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kwiatkowski, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bradley, C.R., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Abdel-Rahim, M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Facilitators :
From page:
14
To page:
23
(
Total pages:
10
)
Abstract:
Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure. © 1988 S. Karger AG, Basel.
Note:
Related Files :
Animal
intravenous drug administration
oral drug administration
Reverse transdermal drug delivery
transdermal drug administration
עוד תגיות
תוכן קשור
More details
DOI :
10.1159/000210747
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27069
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:28
Scientific Publication
Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry
1
Peck, C.C., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Conner, D.P., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bolden, B.J., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Almirez, R.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kingsley, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Mell, L.D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Murphy, M.G., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Hill, V.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Rowland, L.M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Ezra, D., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Kwiatkowski, T.E., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Bradley, C.R., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Abdel-Rahim, M., Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Outward transcutaneous chemical migration: Implications for diagnostics and dosimetry
Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure. © 1988 S. Karger AG, Basel.
Scientific Publication
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