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פותח על ידי קלירמאש פתרונות בע"מ -
Cloning and characterization of FAM13A1 - A gene near a milk protein QTL on BTA6: Evidence for population-wide linkage disequilibrium in Israeli Holsteins
Year:
2004
Source of publication :
genomics (source)
Authors :
ולר, יהודה
;
.
כהן-צינדר, מירי
;
.
סרוסי, אייל
;
.
רון, מיכה
;
.
רייכנשטיין, משה
;
.
שני, משה
;
.
Volume :
84
Co-Authors:
Cohen, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Reichenstein, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Everts-Van Der Wind, A., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Heon-Lee, J., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Shani, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lewin, H.A., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Facilitators :
From page:
374
To page:
383
(
Total pages:
10
)
Abstract:
A cluster of genes coding for proteins of the extracellular matrix (ECM) containing sequence motifs essential for integrin-receptor interactions is located on HSA4q21 and on BTA6, within the critical region of a quantitative trait locus (QTL) affecting milk protein production. Genes within this cluster are involved in the formation of bone and lobuloalveolar structures in mammary gland and in kidney function. We cloned a bovine gene neighboring this ECM cluster, termed FAM13A1, the first member of a novel gene family (FAM13). A short predominant 5.1-kb mRNA variant capable of encoding 697 amino acids is transcribed from 18-exon orthologous genes in human and mouse. All putative protein orthologs contained a bipartite nuclear-localization signal and two coil-coiled domains. We detected two other FAM13 paralogs, C5ORF5 and FAM13C1, on HSA5q31 and HSA10q21, respectively. All FAM13 paralogs produce transcripts that are complementary to adjacent genes, suggesting that antisense transcription may regulate their functions. The structure of a longer 5.9-kb variant, FAM13A1_v2, that has an extra 7-exon putative RhoGAP domain at the N-terminus provides further clues to FAM13 function. Analysis of 400 bulls revealed a population-wide linkage disequilibrium between FAM13A1 polymorphisms and the QTL. © 2004 Elsevier Inc. All rights reserved.
Note:
Related Files :
Animals
cattle
cloning
genomics
Israel
Male
mice
multigene family
nuclear localization signal
RNA
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.ygeno.2004.03.005
Article number:
0
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27240
Last updated date:
03/07/2022 08:56
Creation date:
17/04/2018 00:29
You may also be interested in
Scientific Publication
Cloning and characterization of FAM13A1 - A gene near a milk protein QTL on BTA6: Evidence for population-wide linkage disequilibrium in Israeli Holsteins
84
Cohen, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Reichenstein, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Everts-Van Der Wind, A., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Heon-Lee, J., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Shani, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Lewin, H.A., Department of Animal Sciences, Univ. Illinois at Urbana-Champaign, Urbana, IL 61801, United States
Weller, J.I., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Ron, M., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Seroussi, E., Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan 50250, Israel
Cloning and characterization of FAM13A1 - A gene near a milk protein QTL on BTA6: Evidence for population-wide linkage disequilibrium in Israeli Holsteins
A cluster of genes coding for proteins of the extracellular matrix (ECM) containing sequence motifs essential for integrin-receptor interactions is located on HSA4q21 and on BTA6, within the critical region of a quantitative trait locus (QTL) affecting milk protein production. Genes within this cluster are involved in the formation of bone and lobuloalveolar structures in mammary gland and in kidney function. We cloned a bovine gene neighboring this ECM cluster, termed FAM13A1, the first member of a novel gene family (FAM13). A short predominant 5.1-kb mRNA variant capable of encoding 697 amino acids is transcribed from 18-exon orthologous genes in human and mouse. All putative protein orthologs contained a bipartite nuclear-localization signal and two coil-coiled domains. We detected two other FAM13 paralogs, C5ORF5 and FAM13C1, on HSA5q31 and HSA10q21, respectively. All FAM13 paralogs produce transcripts that are complementary to adjacent genes, suggesting that antisense transcription may regulate their functions. The structure of a longer 5.9-kb variant, FAM13A1_v2, that has an extra 7-exon putative RhoGAP domain at the N-terminus provides further clues to FAM13 function. Analysis of 400 bulls revealed a population-wide linkage disequilibrium between FAM13A1 polymorphisms and the QTL. © 2004 Elsevier Inc. All rights reserved.
Scientific Publication
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