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פותח על ידי קלירמאש פתרונות בע"מ -
PHOTOSENSITIZATION OF CHINESE HAMSTER CELLS BY WATER‐SOLUBLE PHTHALOCYANINES
Year:
1986
Source of publication :
Photochemistry and Photobiology
Authors :
רוזנטל, יונל
;
.
Volume :
43
Co-Authors:
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Center—Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., A.R.O, Department of Food Science, The Volcani Center, P.O. Box 6, Bet-Dagan, Israel
Facilitators :
From page:
615
To page:
619
(
Total pages:
5
)
Abstract:
Abstract— Phthalocyanines are efficient photosensitizers of cultured mammalian cells and are considered for use in photodynamic therapy. The photobiological properties of chloroaluminum phthalocyanine sulfonate (AIPCS) were compared to those of the unsubstituted, water‐insoluble derivative (AIPC). The development of photosensitization after addition of the dye into growth medium is ca. 8 times more rapid for AlPC than for AIPCS. Conversely, the loss of photosensitization when cells are incubated in a dye‐free growth medium following a period of dye uptake, is also faster for AIPC. The dye uptake followed a kinetic behavior similar to the development of photosensitivity, but the loss of dye was too slow for both AlPC and AIPCS to explain loss of photosensitivity. When cells are incubated prior to illumination with AIPCS in phosphate buffered saline instead of growth medium, shorter time and smaller amount of dye are required to achieve the same level of photosensitization. The dependence of photosensitivity on dye concentration is linear for both AIPC and AIPCS. As already found for AIPC, photosensitization by the water‐soluble derivative is also not enhanced in D2O, suggesting that singlet oxygen is not involved in the cytotoxic response. Sodium salicylate, which was found to enhance the effect of AlPC was also effective with AIPCS. This effect is quite specific since the meta and para isomers had no effect. The metal atom complexed with the phthalocyanine ring is significant for the photobiological activity. Among the compounds tested, those containing Al or Zn are most active. Copyright © 1986, Wiley Blackwell. All rights reserved
Note:
Related Files :
Animal
cell line
drug effect
lung
Organometallic Compounds
Radiation Sensitizing Agents
radiosensitizing agent
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1751-1097.1986.tb05636.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27486
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:31
Scientific Publication
PHOTOSENSITIZATION OF CHINESE HAMSTER CELLS BY WATER‐SOLUBLE PHTHALOCYANINES
43
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Center—Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., A.R.O, Department of Food Science, The Volcani Center, P.O. Box 6, Bet-Dagan, Israel
PHOTOSENSITIZATION OF CHINESE HAMSTER CELLS BY WATER‐SOLUBLE PHTHALOCYANINES
Abstract— Phthalocyanines are efficient photosensitizers of cultured mammalian cells and are considered for use in photodynamic therapy. The photobiological properties of chloroaluminum phthalocyanine sulfonate (AIPCS) were compared to those of the unsubstituted, water‐insoluble derivative (AIPC). The development of photosensitization after addition of the dye into growth medium is ca. 8 times more rapid for AlPC than for AIPCS. Conversely, the loss of photosensitization when cells are incubated in a dye‐free growth medium following a period of dye uptake, is also faster for AIPC. The dye uptake followed a kinetic behavior similar to the development of photosensitivity, but the loss of dye was too slow for both AlPC and AIPCS to explain loss of photosensitivity. When cells are incubated prior to illumination with AIPCS in phosphate buffered saline instead of growth medium, shorter time and smaller amount of dye are required to achieve the same level of photosensitization. The dependence of photosensitivity on dye concentration is linear for both AIPC and AIPCS. As already found for AIPC, photosensitization by the water‐soluble derivative is also not enhanced in D2O, suggesting that singlet oxygen is not involved in the cytotoxic response. Sodium salicylate, which was found to enhance the effect of AlPC was also effective with AIPCS. This effect is quite specific since the meta and para isomers had no effect. The metal atom complexed with the phthalocyanine ring is significant for the photobiological activity. Among the compounds tested, those containing Al or Zn are most active. Copyright © 1986, Wiley Blackwell. All rights reserved
Scientific Publication
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