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פותח על ידי קלירמאש פתרונות בע"מ -
FABP4 is a leading candidate gene associated with residual feed intake in growing holstein calves
Year:
2016
Source of publication :
Physiological Genomics
Authors :
ברוש, אריה
;
.
כהן-צינדר, מירי
;
.
שבתאי, אריאל
;
.
Volume :
48
Co-Authors:
Cohen-Zinder, M., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Asher, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel, Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Lipkin, E., Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel
Feingersch, R., Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Agmon, R., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Karasik, D., Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Brosh, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Shabtay, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Facilitators :
From page:
367
To page:
376
(
Total pages:
10
)
Abstract:
Ecological and economic concerns drive the need to improve feed utilization by domestic animals. Residual feed intake (RFI) is one of the most acceptable measures for feed efficiency (FE). However, phenotyping RFI-related traits is complex and expensive and requires special equipment. Advances in marker technology allow the development of various DNA-based selection tools. To assimilate these technologies for the benefit of RFI-based selection, reliable phenotypic measures are prerequisite. In the current study, we identified single nucleotide polymorphisms (SNPs) associated with RFI phenotypic consistency across different ages and diets (named RFI 1-3), using DNA samples of high or low RFI ranked Holstein calves. Using targeted sequencing of chromosomal regions associated with FE- and RFI-related traits, we identified 48 top SNPs significantly associated with at least one of three defined RFIs. Eleven of these SNPs were harbored by the fatty acid binding protein 4 (FABP4). While 10 significant SNPs found in FABP4 were common for RFI 1 and RFI 3, one SNP (FABP4_5; A < G substitution), in the promoter region of the gene, was significantly associated with all three RFIs. As the three RFI classes reflect changing diets and ages with concomitant RFI phenotypic consistency, the above polymorphisms and in particular FABP4_5, might be considered possible markers for RFI-based selection for FE in the Holstein breed, following a larger-scale validation. © 2016 the American Physiological Society.
Note:
Related Files :
Candidate genes
cattle
FABP4
QTL
Residual feed intake
עוד תגיות
תוכן קשור
More details
DOI :
10.1152/physiolgenomics.00121.2015
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27488
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:31
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Scientific Publication
FABP4 is a leading candidate gene associated with residual feed intake in growing holstein calves
48
Cohen-Zinder, M., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Asher, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel, Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel
Lipkin, E., Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel
Feingersch, R., Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Agmon, R., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Karasik, D., Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Brosh, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
Shabtay, A., Beef cattle section, Newe-Ya’ar Research Center, Agricultural Research Organization, Ramat Yishay, Israel
FABP4 is a leading candidate gene associated with residual feed intake in growing holstein calves
Ecological and economic concerns drive the need to improve feed utilization by domestic animals. Residual feed intake (RFI) is one of the most acceptable measures for feed efficiency (FE). However, phenotyping RFI-related traits is complex and expensive and requires special equipment. Advances in marker technology allow the development of various DNA-based selection tools. To assimilate these technologies for the benefit of RFI-based selection, reliable phenotypic measures are prerequisite. In the current study, we identified single nucleotide polymorphisms (SNPs) associated with RFI phenotypic consistency across different ages and diets (named RFI 1-3), using DNA samples of high or low RFI ranked Holstein calves. Using targeted sequencing of chromosomal regions associated with FE- and RFI-related traits, we identified 48 top SNPs significantly associated with at least one of three defined RFIs. Eleven of these SNPs were harbored by the fatty acid binding protein 4 (FABP4). While 10 significant SNPs found in FABP4 were common for RFI 1 and RFI 3, one SNP (FABP4_5; A < G substitution), in the promoter region of the gene, was significantly associated with all three RFIs. As the three RFI classes reflect changing diets and ages with concomitant RFI phenotypic consistency, the above polymorphisms and in particular FABP4_5, might be considered possible markers for RFI-based selection for FE in the Holstein breed, following a larger-scale validation. © 2016 the American Physiological Society.
Scientific Publication
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