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European Journal of Radiology
Eshed, I., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Trattnig, S., Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Sharon, M., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Arbel, R., Center for Sports Medicine, Sourasky Medical Center, Tel Aviv, Israel
Nierenberg, G., Department of Orthopedics, Rambam Health Care Campus, Haifa, Israel
Konen, E., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yayon, A., ProChon Biotech, Ness Ziona, Israel
Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart™II, a second generation matrix-assisted implantation system. Methods: Thirty-one patients were recruited 6-49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. Results: IKDC score significantly correlated with MOCART score (r = -0.39, p = 0.031), inversely correlated with previous interventions (r = -0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). T2 values were significantly lower in patients with longer duration implants (p < 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. Conclusions: Significant improvement with time from BioCart™II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure. © 2011 Elsevier Ireland Ltd. All rights reserved.
פותח על ידי קלירמאש פתרונות בע"מ -
הספר "אוצר וולקני"
אודות
תנאי שימוש
Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome
81
Eshed, I., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Trattnig, S., Department of Radiology, University Hospital of Vienna, Medical University of Vienna, Vienna, Austria
Sharon, M., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Arbel, R., Center for Sports Medicine, Sourasky Medical Center, Tel Aviv, Israel
Nierenberg, G., Department of Orthopedics, Rambam Health Care Campus, Haifa, Israel
Konen, E., Department of Diagnostic Imaging, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Yayon, A., ProChon Biotech, Ness Ziona, Israel
Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome
Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart™II, a second generation matrix-assisted implantation system. Methods: Thirty-one patients were recruited 6-49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. Results: IKDC score significantly correlated with MOCART score (r = -0.39, p = 0.031), inversely correlated with previous interventions (r = -0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). T2 values were significantly lower in patients with longer duration implants (p < 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. Conclusions: Significant improvement with time from BioCart™II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure. © 2011 Elsevier Ireland Ltd. All rights reserved.
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