Co-Authors:
Lev, Z., Department of Biology, Technion - Israel Institute of Technology, Haifa, 32000, Israel
Segev, O., Department of Biology, Technion - Israel Institute of Technology, Haifa, 32000, Israel
Abstract:
This article describes the expression of the Drosophila src gene located at 64B. The gene extends over at least 7 kb of genomic DNA, and codes for three transcripts which are 3.0, 4.4 and 4.8 kb long. Their 3′ ends were identified and tentatively located on the physical map of the gene. All three transcripts are in the same polarity and contain the information required for translating the protein kinase domain common to all members of the src gene family. The Drosophila src transcripts are expressed in two different patterns during development. The 3.0 and 4.4 transcripts are abundant in unfertilized eggs and during embryogenesis. Their prevalence decreases under the limit of detection in the larval and pupal stages, and they reappear in adult flies. The larger 4.8 kb transcript is undetectable in unfertilized eggs. It starts accumulating between 2 and 5 h after fertilization, and is expressed continuously during development. © 1986.