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פותח על ידי קלירמאש פתרונות בע"מ -
The complement of enzymatic sets in different species
Year:
2005
Source of publication :
Journal of Molecular Biology
Authors :
פרייליך, שירי
;
.
Volume :
349
Co-Authors:
Freilich, S., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
Spriggs, R.V., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom, Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
George, R.A., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom, Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Al-Lazikani, B., Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Swindells, M., Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Thornton, J.M., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
Facilitators :
From page:
745
To page:
763
(
Total pages:
19
)
Abstract:
We present here a comprehensive analysis of the complement of enzymes in a large variety of species. As enzymes are a relatively conserved group there are several classification systems available that are common to all species and link a protein sequence to an enzymatic function. Enzymes are therefore an ideal functional group to study the relationship between sequence expansion, functional divergence and phenotypic changes. By using information retrieved from the well annotated SWISS-PROT database together with sequence information from a variety of fully sequenced genomes and information from the EC functional scheme we have aimed here to estimate the fraction of enzymes in genomes, to determine the extent of their functional redundancy in different domains of life and to identify functional innovations and lineage specific expansions in the metazoa lineage. We found that prokaryote and eukaryote species differ both in the fraction of enzymes in their genomes and in the pattern of expansion of their enzymatic sets. We observe an increase in functional redundancy accompanying an increase in species complexity. A quantitative assessment was performed in order to determine the degree of functional redundancy in different species. Finally, we report a massive expansion in the number of mammalian enzymes involved in signalling and degradation. © 2005 Elsevier Ltd. All rights reserved.
Note:
Related Files :
Animals
bioinformatics
enzymes
Genome
Mammalia
phenotype
proteomics
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/j.jmb.2005.04.027
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27862
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:34
Scientific Publication
The complement of enzymatic sets in different species
349
Freilich, S., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
Spriggs, R.V., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom, Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
George, R.A., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom, Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Al-Lazikani, B., Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Swindells, M., Inpharmatica Ltd., 60 Charlotte Street, London W1T 2NU, United Kingdom
Thornton, J.M., EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
The complement of enzymatic sets in different species
We present here a comprehensive analysis of the complement of enzymes in a large variety of species. As enzymes are a relatively conserved group there are several classification systems available that are common to all species and link a protein sequence to an enzymatic function. Enzymes are therefore an ideal functional group to study the relationship between sequence expansion, functional divergence and phenotypic changes. By using information retrieved from the well annotated SWISS-PROT database together with sequence information from a variety of fully sequenced genomes and information from the EC functional scheme we have aimed here to estimate the fraction of enzymes in genomes, to determine the extent of their functional redundancy in different domains of life and to identify functional innovations and lineage specific expansions in the metazoa lineage. We found that prokaryote and eukaryote species differ both in the fraction of enzymes in their genomes and in the pattern of expansion of their enzymatic sets. We observe an increase in functional redundancy accompanying an increase in species complexity. A quantitative assessment was performed in order to determine the degree of functional redundancy in different species. Finally, we report a massive expansion in the number of mammalian enzymes involved in signalling and degradation. © 2005 Elsevier Ltd. All rights reserved.
Scientific Publication
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