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פותח על ידי קלירמאש פתרונות בע"מ -
Effect of inhibitors of plant cell division on mammalian tumor cells in vitro
Year:
1981
Source of publication :
Cancer Research
Authors :
זילכה, שמואל
;
.
Volume :
41
Co-Authors:
Zilkah, S., Section of Medical Oncology, University Hospital, 75 East Newton St., Boston, Mass., 02118, United States, Division of Pediatric Hematology-Oncology, Department of Pediatrics, Boston City Hospiti, 02118, Boston, United States, Department of Medicine, Department of Pediatrics, Boston University School of Medicine, 02118, Massachusetts, Boston, United States
Facilitators :
From page:
1879
To page:
1883
(
Total pages:
5
)
Abstract:
We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor cell cultures, EL-4 and L1210. Four compounds [propham, chlorpropham, bensulide S-(O, O-diisopropylphospho-rodithioate) ester of N-(2-mercaptoethyl)benzenesulfonamide) and siduron] had a 50% inhibitory dose less than 10~4M; six [2,3,5-triiodobenzoic acid, (2,4-dichlorophenoxy)acetic acid, bromacil, (2,4,5-trichlorophenoxy)acetic acid, naptalam, and (4-chloro-2-methylphenoxy)acetic acid] had a 50% inhibitory dose between 10–4 and 10-3M, and the remaining four 2,3: 4,6-di-O-isopropylidene-2-keto-L-gulonate, eptam, maleic hydrazide, and 4-(methylsulfonyl)-2,6-dinitro-N, N,-dipropylaniline] had a 50% inhibitory dose at higher than 10~3M. There was a significant correlation between the effect on the two cell lines as well as between the inhibition of cell proliferation and that of thymidine and leucine uptake. More detailed study of cell proliferation and leucine and thymidine uptake for bensulide and 2,3,5-triiodobenzoic acid revealed a dose-response pattern of inhibition starting shortly after exposure of the cells to the compounds. These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor cells. © 1981, American Association for Cancer Research. All rights reserved.
Note:
Related Files :
Animal
animal experiment
Bromacil
herbicides
mice
עוד תגיות
תוכן קשור
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DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
27917
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:35
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Scientific Publication
Effect of inhibitors of plant cell division on mammalian tumor cells in vitro
41
Zilkah, S., Section of Medical Oncology, University Hospital, 75 East Newton St., Boston, Mass., 02118, United States, Division of Pediatric Hematology-Oncology, Department of Pediatrics, Boston City Hospiti, 02118, Boston, United States, Department of Medicine, Department of Pediatrics, Boston University School of Medicine, 02118, Massachusetts, Boston, United States
Effect of inhibitors of plant cell division on mammalian tumor cells in vitro
We studied the activity of 14 compounds, all of which have been shown to interfere in plant cell division, in two animal tumor cell cultures, EL-4 and L1210. Four compounds [propham, chlorpropham, bensulide S-(O, O-diisopropylphospho-rodithioate) ester of N-(2-mercaptoethyl)benzenesulfonamide) and siduron] had a 50% inhibitory dose less than 10~4M; six [2,3,5-triiodobenzoic acid, (2,4-dichlorophenoxy)acetic acid, bromacil, (2,4,5-trichlorophenoxy)acetic acid, naptalam, and (4-chloro-2-methylphenoxy)acetic acid] had a 50% inhibitory dose between 10–4 and 10-3M, and the remaining four 2,3: 4,6-di-O-isopropylidene-2-keto-L-gulonate, eptam, maleic hydrazide, and 4-(methylsulfonyl)-2,6-dinitro-N, N,-dipropylaniline] had a 50% inhibitory dose at higher than 10~3M. There was a significant correlation between the effect on the two cell lines as well as between the inhibition of cell proliferation and that of thymidine and leucine uptake. More detailed study of cell proliferation and leucine and thymidine uptake for bensulide and 2,3,5-triiodobenzoic acid revealed a dose-response pattern of inhibition starting shortly after exposure of the cells to the compounds. These results indicate that some inhibitors of plant cell division are capable of inhibiting the proliferation of animal tumor cells. © 1981, American Association for Cancer Research. All rights reserved.
Scientific Publication
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