אסיף מאגר המחקר החקלאי

Genome, transcriptome, and functional analyses of Penicillium expansum provide new insights into secondary metabolism and pathogenicity

Year:

2015

Source of publication :

Authors :

Volume :

28

Co-Authors:

Ballester, A.-R., Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Avda. Agustin Escardino 7, Paterna, Valencia, Spain
Marcet-Houben, M., Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Dr. Aiguader, 88, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain
Levin, E., Department of Postharvest Science, ARO, Volcani Center, P.O.Box 6, Bet Dagan, Israel
Sela, N., Department of Postharvest Science, ARO, Volcani Center, P.O.Box 6, Bet Dagan, Israel
Selma-Lázaro, C., Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Avda. Agustin Escardino 7, Paterna, Valencia, Spain
Carmona, L., Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Avda. Agustin Escardino 7, Paterna, Valencia, Spain, Food Science and Tecnhonolgy Department, Universidad de Santiago de Chile, Obispo Umaña 050, Estación-Central, Chile
Wisniewski, M., Appalachian Fruit Research Station, USDA-ARS, 2217 Wiltshire Road, Kearneysville, WV, United States
Droby, S., Department of Postharvest Science, ARO, Volcani Center, P.O.Box 6, Bet Dagan, Israel
González-Candelas, L., Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Avda. Agustin Escardino 7, Paterna, Valencia, Spain
Gabaldón, T., Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Dr. Aiguader, 88, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, Barcelona, Spain

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Abstract:

The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples. © 2015 The American Phytopathological Society.

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