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פותח על ידי קלירמאש פתרונות בע"מ -
PHOTOSENSITIZED INACTIVATION OF CHINESE HAMSTER CELLS BY PHTHALOCYANINES
Year:
1985
Source of publication :
Photochemistry and Photobiology
Authors :
רוזנטל, יונל
;
.
Volume :
42
Co-Authors:
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., A.R.O, Department of Food Science, Volcani Center, P.O. Box 6, Bet-Dagan, Israel
Facilitators :
From page:
129
To page:
133
(
Total pages:
5
)
Abstract:
Chloroaluminum phthalocyanine was found to sensitize cultured Chinese hamster cells upon exposure to white fluorescent light. Elimination of wavelengths below 370 nm did not reduce the effect significantly, indicating that the effective wavelengths were those absorbed by the Q band (600–700 nm) of phthalocyanine. The magnitude of the photosensitizing effect increased with the dye concentration and the time of its contact with the cells prior to light exposure. Although photosensitization was drastically reduced in the absence of oxygen, the lack of effect of glycerol and D20 during exposure suggests that neither hydroxyl radicals nor 1O2 are responsible for the cytotoxic response. The efficiency of the photosensitized induced cell killing did not vary with the position of the cells in the cell cycle, in contrast to exposure to X‐rays. The improved spectral properties, the reported low toxicity and the selective retention by neoplasms, make phthalocyanines promising candidates for use in photodynamic therapy of cancer. Copyright © 1985, Wiley Blackwell. All rights reserved
Note:
Related Files :
Animal
article
cell line
cell survival
Cricetulus
drug effect
Hamsters
Kidney
light
phthalocyanine
Pigments
עוד תגיות
תוכן קשור
More details
DOI :
10.1111/j.1751-1097.1985.tb01550.x
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
28033
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:36
Scientific Publication
PHOTOSENSITIZED INACTIVATION OF CHINESE HAMSTER CELLS BY PHTHALOCYANINES
42
Ben‐Hur, E., Department of Radiobiology, Nuclear Research Center-Negev, P.O. Box 9001, Beer-Sheva, Israel
Rosenthal, I., A.R.O, Department of Food Science, Volcani Center, P.O. Box 6, Bet-Dagan, Israel
PHOTOSENSITIZED INACTIVATION OF CHINESE HAMSTER CELLS BY PHTHALOCYANINES
Chloroaluminum phthalocyanine was found to sensitize cultured Chinese hamster cells upon exposure to white fluorescent light. Elimination of wavelengths below 370 nm did not reduce the effect significantly, indicating that the effective wavelengths were those absorbed by the Q band (600–700 nm) of phthalocyanine. The magnitude of the photosensitizing effect increased with the dye concentration and the time of its contact with the cells prior to light exposure. Although photosensitization was drastically reduced in the absence of oxygen, the lack of effect of glycerol and D20 during exposure suggests that neither hydroxyl radicals nor 1O2 are responsible for the cytotoxic response. The efficiency of the photosensitized induced cell killing did not vary with the position of the cells in the cell cycle, in contrast to exposure to X‐rays. The improved spectral properties, the reported low toxicity and the selective retention by neoplasms, make phthalocyanines promising candidates for use in photodynamic therapy of cancer. Copyright © 1985, Wiley Blackwell. All rights reserved
Scientific Publication
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