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פותח על ידי קלירמאש פתרונות בע"מ -
Reciprocal activation of HSF1 and HSF3 in brain and blood tissues: Is redundancy developmentally related?
Year:
2006
Authors :
שבתאי, אריאל
;
.
Volume :
291
Co-Authors:
Shabtay, A., Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel, Department of Cattle and Genetic Sciences, Institute of Animal Science, Newe-Ya'ar Research Center, Ramat Yishay, Israel
Arad, Z., Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel, Dept. of Biology, Technion, Haifa, 32000, Israel
Facilitators :
From page:
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Total pages:
1
)
Abstract:
Transcriptional induction of heat-shock genes in response to temperature elevation and other stresses is mediated by heat-shock transcription factors (HSFs). Avian cells express two redundant heat-shock responsive factors, HSF1 and HSF3, which differ in their activation kinetics and threshold induction temperature. Unlike the ubiquitous activation of HSF1, the DNA-binding activity of HSF3 is restricted to undifferentiated avian cells and embryonic tissues. Herein, we report a reciprocal activation of HSF1 and HSF3 in vivo. Whereas HSF1 mediates transcriptional activity only in the brain upon severe heat shock, HSF3 is exclusively activated in blood cells upon light, moderate, and severe heat shock, promoting induction of heat-shock genes. Although not activated, HSF1 is expressed in blood cell nuclei in a granular appearance, suggesting regulation of genes other than heat-shock genes. Intraspecific comparison of heat-sensitive and heat-resistant fowl strains indicates that the unique activation pattern of HSF3 in blood tissue is a general phenomenon, not related to thermal history. Taken together, HSF1 and HSF3 mediate transcriptional activity of adult tissues and differentiated cells in a nonredundant manner. Instead, an exclusive, tissue-specific activation is observed, implying that redundancy may be developmentally related. The physiological and developmental implications are discussed. Copyright © 2006 the American Physiological Society.
Note:
Related Files :
animal experiment
Animals
animal tissue
blood vessel
Chickens
DNA
Heat-Shock Proteins
heat tolerance
unclassified drug
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DOI :
10.1152/ajpregu.00685.2005
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
28339
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:38
Scientific Publication
Reciprocal activation of HSF1 and HSF3 in brain and blood tissues: Is redundancy developmentally related?
291
Shabtay, A., Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel, Department of Cattle and Genetic Sciences, Institute of Animal Science, Newe-Ya'ar Research Center, Ramat Yishay, Israel
Arad, Z., Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel, Dept. of Biology, Technion, Haifa, 32000, Israel
Reciprocal activation of HSF1 and HSF3 in brain and blood tissues: Is redundancy developmentally related?
Transcriptional induction of heat-shock genes in response to temperature elevation and other stresses is mediated by heat-shock transcription factors (HSFs). Avian cells express two redundant heat-shock responsive factors, HSF1 and HSF3, which differ in their activation kinetics and threshold induction temperature. Unlike the ubiquitous activation of HSF1, the DNA-binding activity of HSF3 is restricted to undifferentiated avian cells and embryonic tissues. Herein, we report a reciprocal activation of HSF1 and HSF3 in vivo. Whereas HSF1 mediates transcriptional activity only in the brain upon severe heat shock, HSF3 is exclusively activated in blood cells upon light, moderate, and severe heat shock, promoting induction of heat-shock genes. Although not activated, HSF1 is expressed in blood cell nuclei in a granular appearance, suggesting regulation of genes other than heat-shock genes. Intraspecific comparison of heat-sensitive and heat-resistant fowl strains indicates that the unique activation pattern of HSF3 in blood tissue is a general phenomenon, not related to thermal history. Taken together, HSF1 and HSF3 mediate transcriptional activity of adult tissues and differentiated cells in a nonredundant manner. Instead, an exclusive, tissue-specific activation is observed, implying that redundancy may be developmentally related. The physiological and developmental implications are discussed. Copyright © 2006 the American Physiological Society.
Scientific Publication
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