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פותח על ידי קלירמאש פתרונות בע"מ -
The effect of the plant cell inhibitor propachlor (α-chloro-N-isopropyl-acetanilide) on the cell cycle of L1210 cells as evaluated by flow cytometry
Year:
1985
Source of publication :
Life Sciences
Authors :
זילכה, שמואל
;
.
Volume :
36
Co-Authors:
Zilkah, S., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States
Osband, M., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States, Departments of Medicine and Pediatrics, Boston University School of Medicine, Boston, MA, United States
McCaffrey, R., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States
Shapiro, H., Laboratory of Cytokinetics, Sidney Farber Cancer Institute, Department of Pathology, Boston, MA, United States
Facilitators :
From page:
2111
To page:
2115
(
Total pages:
5
)
Abstract:
Previously it was reported that the herbicide propachlor (α-chloro-N-isopropyl-acetanilide) has a strong inhibitory effect on the proliferation of L1210 mouse leukemia cells. It is now demonstrated that propachlor treatment causes L1210 cells to accumulate in the G1 phase as determined by flow cytometric analysis. This effect of propachlor is dose-dependent with more than 90% of G1 cells accumulating at 10μM. Kinetic experiments demonstrated that the accumulation of cells in G1 starts in about 10 hours, and increased for up to about 44 hours of incubation with 10μM propachlor. Treated cells can be revised to a normal DNA distribution by removing propachlor. © 1985.
Note:
Related Files :
Acetanilides
Animal
blood and hemopoietic system
herbicides
Leukemia L1210
leukemia l 1210
mice
mouse
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0024-3205(85)90307-8
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
28436
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:39
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Scientific Publication
The effect of the plant cell inhibitor propachlor (α-chloro-N-isopropyl-acetanilide) on the cell cycle of L1210 cells as evaluated by flow cytometry
36
Zilkah, S., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States
Osband, M., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States, Departments of Medicine and Pediatrics, Boston University School of Medicine, Boston, MA, United States
McCaffrey, R., Section of Medical Oncology, the Evans Memorial Department of Clinical Research, the Department of Medicine, Boston, MA, United States, Division of Pediatric Hematology-Oncology, the Department of Pediatrics, Boston City Hospital, Boston, MA, United States
Shapiro, H., Laboratory of Cytokinetics, Sidney Farber Cancer Institute, Department of Pathology, Boston, MA, United States
The effect of the plant cell inhibitor propachlor (α-chloro-N-isopropyl-acetanilide) on the cell cycle of L1210 cells as evaluated by flow cytometry
Previously it was reported that the herbicide propachlor (α-chloro-N-isopropyl-acetanilide) has a strong inhibitory effect on the proliferation of L1210 mouse leukemia cells. It is now demonstrated that propachlor treatment causes L1210 cells to accumulate in the G1 phase as determined by flow cytometric analysis. This effect of propachlor is dose-dependent with more than 90% of G1 cells accumulating at 10μM. Kinetic experiments demonstrated that the accumulation of cells in G1 starts in about 10 hours, and increased for up to about 44 hours of incubation with 10μM propachlor. Treated cells can be revised to a normal DNA distribution by removing propachlor. © 1985.
Scientific Publication
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