אסיף מאגר המחקר החקלאי

Tolerance and acceptable daily intake of chlorinated fumigants in the rat diet

Year:

1976

Source of publication :

Authors :

Volume :

14

Co-Authors:

Bondi, A., Faculty of Agriculture, Rehovot, Israel
Herzberg, M., Ichilov Hospital, Tel Aviv, Israel

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Abstract:

Long-term trials were carried out with rats fed mash fumigated with carbon tetrachloride or ethylene dichloride (1,2-dichloroethane). The difficulty of maintaining a constant residual level of fumigant in the feed was overcome by adopting suitable storage and feeding procedures. The amounts of fumigant actually consumed accounted for 60-70% of the residue initially present in the mash. Triglyceride accumulation in the liver was the most sensitive sign of chronic poisoning with carbon tetrachloride and was apparent after only 6 wk of treatment with a daily dose of about 1% of the LD50. Ethylene dichloride caused only a slight increase in liver fat at very high doses. Carbon tetrachloride and ethylene dichloride were each administered to rats for 2 yr in fumigated mash at levels below the obviously harmful ones. Growth, fertility, reproduction and biochemical tests were used as criteria for establishing the no-effect levels. On the basis of these data, acceptable daily intakes of 10 mg/kg body weight for carbon tetrachloride and 25 mg/kg for ethylene dichloride are proposed. The respective tolerances are 100 and 250 ppm. The proposed tolerances in human food are discussed. © 1976 Pergamon Press.

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