אסיף מאגר המחקר החקלאי

Proteome dataset of subcutaneous adipose tissue obtained from late pregnant dairy cows during summer heat stress and winter seasons

Year:

2017

Source of publication :

Authors :

Volume :

12

Co-Authors:

Zachut, M., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Rishon Lezion, Israel
Kra, G., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Rishon Lezion, Israel
Livshitz, L., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Rishon Lezion, Israel
Portnick, Y., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Rishon Lezion, Israel
Yakoby, S., Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, Rishon Lezion, Israel
Friedlander, G., The Ilana and Pascal Mantoux Institute for Bioinformatics, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel
Levin, Y., De Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel

Facilitators :

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Abstract:

Adipose tissue has a central role in the regulation of metabolism in dairy cows, and many proteins expressed in this tissue are involved in metabolic responses to stress (Peinado et al., 2012) [1]. Environmental heat stress is one of the main stressors limiting production in dairy cattle (Fuquay, 1981; West, 2003) [2,3], and there is a complex interaction between heat stress and the transition period from late pregnancy to onset of lactation, which is manifested in heat-stressed late-gestation cows (Tao and Dahl, 2013) [4]. We recently defined the proteome of adipose tissue in peripartum dairy cows, identifying 586 proteins of which 18.9% were differentially abundant in insulin-resistant compared to insulin-sensitive adipose tissue (Zachut, 2015) [5]. That study showed that proteomic techniques constitute a valuable tool for identifying novel biomarkers in adipose tissue that are related to metabolic adaptation to stress in dairy cows. The objective of the present work was to examine the adipose tissue proteome under thermo-neutral or seasonal heat stress conditions in late pregnant dairy cows. We have collected subcutaneous adipose tissue biopsies from 10 late pregnant dairy cows during summer heat stress and from 8 late pregnant dairy cows during winter season, and identified and quantified 1495 proteins in the adipose tissues. This dataset of adipose tissue proteome from dairy cows adds novel information on the variety of proteins that are abundant in this tissue during late pregnancy under thermo-neutral as well as heat stress conditions. Differential abundance of 107 (7.1%) proteins was found between summer and winter adipose. These results are discussed in our recent research article (Zachut et al., 2017) [6]. © 2017 The Authors

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