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Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephalus glaber), when fed on a carrot diet
Year:
1993
Source of publication :
British Journal of Nutrition
Authors :
יהב, שלמה
;
.
Volume :
69
Co-Authors:
Yahav, S., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrandxs, Baragwanath Hospital, PO Bertsham 2013, Johannesburg, South Africa
Buffenstein, R., Physiology Department, University of the Witwatersrand Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa
Facilitators :
From page:
233
To page:
241
(
Total pages:
9
)
Abstract:
Naked mole rats (Heterocephalus glaber) lead a strictly subterranean existence and appear to be naturally deficient in cholecalciferol (D3). Oral supplementation with D3 (Ds) led to a 1-8-fold increase in food intake and the associated enlargement (1-4-fold) of the caecum. The effect of Ds, and the concomitant increase in food intake, on caecal fermentation efficiency when animals were fed on a carrot-based diet was determined by measuring the rate of both gas production and short-chain fatty acid (SCFA) production. Microbial-controlled fermentation processes in the caecum were enhanced with Ds when compared with animals not receiving a D3 supplement (Dn). Both the rates of gas production (Dn 10-76 (se 0-77), Ds 15-20 (se 1-77) ml/g dry matter (DM) per h) and SCFA production (Dn 463-0 (se 33–7), Ds 684-3 (se 74.8) μmol/g DM per h) increased more than 1-4-fold per g DM caecal substrate. These factors contributed to the higher digestibility of the food in Ds animals. The larger quantity of energy available to D3-replete naked mole rats was not used in anabolic processes, for these animals maintained mass. These findings suggest that metabolic rate in D3-replete animals was elevated. Thus, despite improved gut function, D3-replete animals may be disadvantaged by their higher energy and food requirements in their natural milieu. © 1993, The Nutrition Society. All rights reserved.
Note:
Related Files :
Animal
animal experiment
animal tissue
biosynthesis
ecosystem
gastrointestinal tract function
Male
Rodentia
short chain fatty acid
עוד תגיות
תוכן קשור
More details
DOI :
10.1079/BJN19930025
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
28868
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:42
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Scientific Publication
Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephalus glaber), when fed on a carrot diet
69
Yahav, S., MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrandxs, Baragwanath Hospital, PO Bertsham 2013, Johannesburg, South Africa
Buffenstein, R., Physiology Department, University of the Witwatersrand Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa
Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephalus glaber), when fed on a carrot diet
Naked mole rats (Heterocephalus glaber) lead a strictly subterranean existence and appear to be naturally deficient in cholecalciferol (D3). Oral supplementation with D3 (Ds) led to a 1-8-fold increase in food intake and the associated enlargement (1-4-fold) of the caecum. The effect of Ds, and the concomitant increase in food intake, on caecal fermentation efficiency when animals were fed on a carrot-based diet was determined by measuring the rate of both gas production and short-chain fatty acid (SCFA) production. Microbial-controlled fermentation processes in the caecum were enhanced with Ds when compared with animals not receiving a D3 supplement (Dn). Both the rates of gas production (Dn 10-76 (se 0-77), Ds 15-20 (se 1-77) ml/g dry matter (DM) per h) and SCFA production (Dn 463-0 (se 33–7), Ds 684-3 (se 74.8) μmol/g DM per h) increased more than 1-4-fold per g DM caecal substrate. These factors contributed to the higher digestibility of the food in Ds animals. The larger quantity of energy available to D3-replete naked mole rats was not used in anabolic processes, for these animals maintained mass. These findings suggest that metabolic rate in D3-replete animals was elevated. Thus, despite improved gut function, D3-replete animals may be disadvantaged by their higher energy and food requirements in their natural milieu. © 1993, The Nutrition Society. All rights reserved.
Scientific Publication
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