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פותח על ידי קלירמאש פתרונות בע"מ -
Detoxification and synergism of diflubenzuron and chlorfluazuron in the red flour beetle Tribolium castaneum
Year:
1989
Authors :
ישעיה, יצחק
;
.
Volume :
34
Co-Authors:
Gazit, Y., Department of Entomology, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Ishaaya, I., Department of Entomology, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Perry, A.S., Laboratory of Environmental Toxicology, Institute for Nature Conservation Research, Tel-Aviv University, Ramat Aviv, 69978, Israel
Facilitators :
From page:
103
To page:
110
(
Total pages:
8
)
Abstract:
Chlorfluazuron (CFA), a benzoylphenyl urea insecticide, was found to be more potent than diflubenzuron (DFB) against Tribolium castaneum larvae. CFA was 37-fold more toxic than DFB against the fourth instar larvae but only 4-fold more against the first instar. While DFB had no effect on the pupal stage, CFA treatment resulted in a high level of pupa-adult intermediates. DFB was detoxified more rapidly than CFA in the larvae. Of the total amount applied to the larvae, 9% of the DFB could be detected in the pupae as compared with 40% of the CFA. No metabolites of CFA could be detected in either the larvae or the pupae, as compared with a high level of DFB metabolites, i.e., 4-chlorophenyl urea (4-CPU), 4-chloroaniline (4-CA), and polar materials. Hence, the retention time of CFA in the larval body (T1 2 > 100 hr) was much higher than that of DFB (T1 2 {reversed tilde equals} 7 hr). The major metabolites of DFB in the larvae, determined as the percentage of the total recovery, were 4-CPU (6.6%), polar materials (1.8%), and 4-CA (3.6%). Simultaneous treatment of insects with DFB and esterase inhibitors such as phenyl saligenin cyclic phosphonate and S,S,S-tributylphosphorotrithioate resulted in decreased DFB metabolism and an increase in its T1 2 to 9 and 18 hr, respectively. These inhibitors synergized considerably (2- to 3-fold) the larvicidal effect of DFB, but they did not alter the toxicity of CFA. Hence, efficient synergists to DFB, based on inhibition of detoxification, might improve its toxicity and help maintain its rapid biodegradable property in the environment. © 1989.
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More details
DOI :
10.1016/0048-3575(89)90147-8
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
28897
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:42
You may also be interested in
Scientific Publication
Detoxification and synergism of diflubenzuron and chlorfluazuron in the red flour beetle Tribolium castaneum
34
Gazit, Y., Department of Entomology, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Ishaaya, I., Department of Entomology, ARO, The Volcani Center, Bet Dagan, 50250, Israel
Perry, A.S., Laboratory of Environmental Toxicology, Institute for Nature Conservation Research, Tel-Aviv University, Ramat Aviv, 69978, Israel
Detoxification and synergism of diflubenzuron and chlorfluazuron in the red flour beetle Tribolium castaneum
Chlorfluazuron (CFA), a benzoylphenyl urea insecticide, was found to be more potent than diflubenzuron (DFB) against Tribolium castaneum larvae. CFA was 37-fold more toxic than DFB against the fourth instar larvae but only 4-fold more against the first instar. While DFB had no effect on the pupal stage, CFA treatment resulted in a high level of pupa-adult intermediates. DFB was detoxified more rapidly than CFA in the larvae. Of the total amount applied to the larvae, 9% of the DFB could be detected in the pupae as compared with 40% of the CFA. No metabolites of CFA could be detected in either the larvae or the pupae, as compared with a high level of DFB metabolites, i.e., 4-chlorophenyl urea (4-CPU), 4-chloroaniline (4-CA), and polar materials. Hence, the retention time of CFA in the larval body (T1 2 > 100 hr) was much higher than that of DFB (T1 2 {reversed tilde equals} 7 hr). The major metabolites of DFB in the larvae, determined as the percentage of the total recovery, were 4-CPU (6.6%), polar materials (1.8%), and 4-CA (3.6%). Simultaneous treatment of insects with DFB and esterase inhibitors such as phenyl saligenin cyclic phosphonate and S,S,S-tributylphosphorotrithioate resulted in decreased DFB metabolism and an increase in its T1 2 to 9 and 18 hr, respectively. These inhibitors synergized considerably (2- to 3-fold) the larvicidal effect of DFB, but they did not alter the toxicity of CFA. Hence, efficient synergists to DFB, based on inhibition of detoxification, might improve its toxicity and help maintain its rapid biodegradable property in the environment. © 1989.
Scientific Publication
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