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פותח על ידי קלירמאש פתרונות בע"מ -
Epinephrine blood concentrations after peripheral bronchial versus endotracheal administration of epinephrine in dogs
Year:
1992
Source of publication :
Critical Care Medicine
Authors :
עזרא, דוד
;
.
Volume :
20
Co-Authors:
Mazkereth, R., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Paret, G., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Ezra, D., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Aviner, S., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Peleg, E., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Rosenthal, T., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Barzilay, Z., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Facilitators :
From page:
1582
To page:
1587
(
Total pages:
6
)
Abstract:
Background and Methods: Emergency endotracheal drug administration has become an acceptable route for drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each intratracheal drug administration. Results: Both routes of epinephrine administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine administration (maximal concentration 8.9 ± 3.2 vs. 2.0 ± 0.4 ng/mL), and the total dose absorbed was significantly (76.5 ± 13.5 vs. 36.7 ± 6.5 ng/min/mL, p < .05) higher. The time interval to reach maximal concentration was significantly shorter with the peripheral bronchial dosing than with the endotracheal route (1.3 ± 0.2 vs. 2.7 ± 0.5 min, p < .05). Neither group demonstrated a significant change in heart rate, and both had similar, minor decreases in BP for >2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. Conclusions: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.
Note:
Related Files :
Animal
animal experiment
Bronchi
chromatography
Female
Male
Resuscitation
עוד תגיות
תוכן קשור
More details
DOI :
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29029
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:43
Scientific Publication
Epinephrine blood concentrations after peripheral bronchial versus endotracheal administration of epinephrine in dogs
20
Mazkereth, R., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Paret, G., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Ezra, D., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Aviner, S., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Peleg, E., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Rosenthal, T., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Barzilay, Z., Pediatric Intensive Care Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel
Epinephrine blood concentrations after peripheral bronchial versus endotracheal administration of epinephrine in dogs
Background and Methods: Emergency endotracheal drug administration has become an acceptable route for drug delivery during cardiopulmonary resuscitation. The purpose of the present study was to determine whether the site of endotracheal epinephrine injection is an important factor in its absorption. Epinephrine (1:1000), in a dose of 0.02 mg/kg diluted in 2 mL of saline, was given to ten anesthetized mongrel dogs. Each dog was studied twice: once when the epinephrine was injected into the endotracheal tube, and on another day, through the endotracheal tube via a flexible catheter wedged into a peripheral bronchus. Arterial blood samples for plasma epinephrine concentration determinations were collected, before and at 1, 2, 5, 10, 15, and 30 mins after each intratracheal drug administration. Results: Both routes of epinephrine administration significantly increased plasma concentrations within 1 min of injection. Higher plasma epinephrine concentrations were achieved after peripheral bronchial epinephrine administration (maximal concentration 8.9 ± 3.2 vs. 2.0 ± 0.4 ng/mL), and the total dose absorbed was significantly (76.5 ± 13.5 vs. 36.7 ± 6.5 ng/min/mL, p < .05) higher. The time interval to reach maximal concentration was significantly shorter with the peripheral bronchial dosing than with the endotracheal route (1.3 ± 0.2 vs. 2.7 ± 0.5 min, p < .05). Neither group demonstrated a significant change in heart rate, and both had similar, minor decreases in BP for >2 to 5 mins. There were no significant differences between the arterial blood gases of the two groups at various stages of the experiment. Conclusions: In dogs, epinephrine administered via the peripheral bronchial route has a clear pharmacologic advantage over the endotracheal route. This advantage may be more important during cardiopulmonary resuscitation conditions and other low flow states, and may account for the failure observed with the endotracheal route in recently published clinical reports.
Scientific Publication
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