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פותח על ידי קלירמאש פתרונות בע"מ -
Substance K: Vascular and cardiac effects in rat and pig
Year:
1985
Source of publication :
peptides (מקור פרסום )
Authors :
עזרא, דוד
;
.
Volume :
6
Co-Authors:
Eimerl, J., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Bayorh, M.A., Morehouse School of Medicine, Department of Pharmacology, Atlanta, GA 30310, United States
Zukowska-Grojec, Z., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Faden, A.I., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Ezra, D., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Feuerstein, G., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Facilitators :
From page:
149
To page:
153
(
Total pages:
5
)
Abstract:
The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg8-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli. © 1985.
Note:
Related Files :
animal experiment
Animals
heart rate
Male
Neuromedins
propranolol
Substance K
עוד תגיות
תוכן קשור
More details
DOI :
10.1016/0196-9781(85)90148-2
Article number:
Affiliations:
Database:
סקופוס
Publication Type:
מאמר
;
.
Language:
אנגלית
Editors' remarks:
ID:
29241
Last updated date:
02/03/2022 17:27
Creation date:
17/04/2018 00:45
Scientific Publication
Substance K: Vascular and cardiac effects in rat and pig
6
Eimerl, J., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Bayorh, M.A., Morehouse School of Medicine, Department of Pharmacology, Atlanta, GA 30310, United States
Zukowska-Grojec, Z., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Faden, A.I., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Ezra, D., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Feuerstein, G., Neurobiology Research Division, Department of Neurology Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, United States
Substance K: Vascular and cardiac effects in rat and pig
The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg8-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli. © 1985.
Scientific Publication
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