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Journal of Urology
Selman, S.H., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Kreimer-Birnbaum, M., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Chaudhuri, K., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Garbo, G.M.
Seaman, D.A.
Keck, R.W.
Ben-Hur, E.
Rosenthal, I.
Chloroaluminium tetrasulfophthalocyanine (AlPCS) was used as a photosensitizer for the photodynamic treatment of transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) induced urothelial tumors. Two groups of six rats each were injected with AlPCS (three μg./gm. body weight) and 24 hours after injection underwent photodynamic treatment with red light (>590 nm., 360 joules/cm.2). Tumors examined four hours (Group I) and 24 hours (Group II) after the completion of phototreatment showed extensive hemorrhagic necrosis. Tumors treated with AlCPS alone showed no changes. In two other groups of six rats each, blood flow to tumors treated with AlPCS alone (Group III) and AlPCS plus light (Group IV) was measured using the radioactive microsphere technique. AlCPS plus light resulted in a significant decrease (p<.05) in tumor blood flow within 10 minutes of completion of phototreatment while AlCPS alone had no effect on tumor blood flow. These findings are similar to those observed when higher doses (10 μg./gm. to 20 μg./gm. body weight) of hematoporphyrin derivative (HpD) and light were used for phototreatment of FANFT induced tumors. AlCPS is a stable sulfonated derivative of tetraazotetrabenzoporphyrin which absorbs maximally in the red portion of the visible spectrum, a region with good tissue penetration properties. These studies suggest the AlPCS may be a useful new agent for photodynamic therapy of cancer.
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Photodynamic treatment of transplantable bladder tumors in rodents after pretreatment with chloroaluminium tetrasulfophthalocyanine
136
Selman, S.H., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Kreimer-Birnbaum, M., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Chaudhuri, K., Department of Surgery, Medical College of Ohio, Toledo, OH 43699, United States
Garbo, G.M.
Seaman, D.A.
Keck, R.W.
Ben-Hur, E.
Rosenthal, I.
Photodynamic treatment of transplantable bladder tumors in rodents after pretreatment with chloroaluminium tetrasulfophthalocyanine
Chloroaluminium tetrasulfophthalocyanine (AlPCS) was used as a photosensitizer for the photodynamic treatment of transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) induced urothelial tumors. Two groups of six rats each were injected with AlPCS (three μg./gm. body weight) and 24 hours after injection underwent photodynamic treatment with red light (>590 nm., 360 joules/cm.2). Tumors examined four hours (Group I) and 24 hours (Group II) after the completion of phototreatment showed extensive hemorrhagic necrosis. Tumors treated with AlCPS alone showed no changes. In two other groups of six rats each, blood flow to tumors treated with AlPCS alone (Group III) and AlPCS plus light (Group IV) was measured using the radioactive microsphere technique. AlCPS plus light resulted in a significant decrease (p<.05) in tumor blood flow within 10 minutes of completion of phototreatment while AlCPS alone had no effect on tumor blood flow. These findings are similar to those observed when higher doses (10 μg./gm. to 20 μg./gm. body weight) of hematoporphyrin derivative (HpD) and light were used for phototreatment of FANFT induced tumors. AlCPS is a stable sulfonated derivative of tetraazotetrabenzoporphyrin which absorbs maximally in the red portion of the visible spectrum, a region with good tissue penetration properties. These studies suggest the AlPCS may be a useful new agent for photodynamic therapy of cancer.
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